The association between genetic polymorphisms of the interleukin-10, tumor necrosis factor-alpha, and annexin A5 gene loci and restenosis after percutaneous coronary angioplasty and stenting.
Advances in technology for percutaneous coronary angioplasty, such as coated stents, has reduced complications, but restenosis remains a significant clinical problem. Factors associated with an increased risk of restenosis included diabetes mellitus and coronary artery disease a few.
It is also possible that genetic factors play a role in restenosis although there is little data on this. We have investigated the association of three genetic markers of genes involved in inflammation that leads to this restenosis.In case-control study, 306 patients were considered to be related to Iran on the basis of clinical restenosis investigated.
Based on the results of angiography, 104 patients were found to have a> 50% stenosis within a stent implant, and is allocated to a group in-stent restenosis (ISR); 202 patients without in-stent stenosis or stenosis ≤50% was allocated to the non-ISR (NISR). Demographic data were collected from medical records. Biochemical parameters were measured using routine methods. Genotype interleukin-10 (IL-10), annexin A5 (AnxA5), and tumor necrosis factor-alpha (TNF) locus is determined by using real-time polymerase chain reaction and high resolution melting test.
result Fasting blood glucose, serum triglycerides, and serum high sensitivity C-reactive protein (hs-CRP) concentrations were higher in the ISR compared NISR group (P <0.05), and history of diabetes mellitus was significantly associated with the presence of restenosis (P <0.001). There is no significant difference in the frequency of genetic polymorphisms of IL-10, AnxA5, and the TNF gene and the ISR.
After adjustment for clinical variables, genetic polymorphisms in the IL-10, TNF, and ANXA5 gene locus does not appear to be a risk factor for> 50% of ISR in our population. However, our data suggest a significant association between diabetes mellitus, serum hs-CRP, the type of stent, and restenosis.
The association between genetic polymorphisms of the interleukin-10, tumor necrosis factor-alpha, and annexin A5 gene loci and restenosis after percutaneous coronary angioplasty and stenting.
Genetic variation in the interleukin-7 is associated with reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum.
Severe malaria anemia (SMA) is a major cause of malaria-related morbidity and mortality in children. Genetic factors that influence the development and erythropoiesis inefficient SMA, SMA central pathogenic feature, only a portion of the pilot understood.We Genome-wide Association Study (GWAS) in children with Plasmodium falciparum. The GWAS was performed using Infinium® Illumina® HD Super Assay in conjunction with the Human Illumina’s® Omni2.5-8v1 BeadChip (with> 2.45 M markers). Data were analyzed using logistic regression analysis of single SNP with legacy control additive model covariates.
The results of the pilot global genomics research we identified that the variation in the interleukin (IL) -7 is associated with an enhanced risk of SMA. To validate these findings, we investigated the relationship between genotype and / or haplotype of two single nucleotide polymorphisms (SNPs) in IL7 [72 194 T / C and – 2440 A / G] and susceptibility to both high school and erythropoiesis inefficient [ie, production of reticulocytes index (RPI) <2.0 in children anemia (Hb <11.0 g / dL).
Description: A sandwich quantitative ELISA assay kit for detection of Canine Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Canine Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Equine Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Equine Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Goat Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Goat Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Monkey Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Monkey Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig Interleukin 2 (IL2) in samples from serum, plasma, tissue homogenates or other biological fluids.
Description: Recombinant Rat Interleukin 2 expressed in: E.coli
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Children presenting with P. falciparum malaria (<3 years, n = 883) are grouped into two groups: uncomplicated malaria (UM, n = 718) and high school (n = 165) regression model, controlling for confounding associated anemia-, revealing that the transport of the TC genotype at position 72 194 T / C is associated with an increased susceptibility to inefficient erythropoiesis (OR = 1.90; 95% CI 1.09 to 3.30; P = 0.02) as homozygous CC (OR 5.14 ; 95% CI = 1.20 to 21.99; P = 0.03).
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