Serum interleukin-18 levels as a predictor for patients with genetic dysfunction of cytochrome P450 2C19 in dual antiplatelet therapy with clopidogrel

Serum interleukin-18 levels as a predictor for patients with genetic dysfunction of cytochrome P450 2C19 in dual antiplatelet therapy with clopidogrel

Background: P2Y12 Reaction Units (PRU) is an index of platelet activity after treatment with clopidogrel. Apart from the reactions of the P2Y12 fit in dual antiplatelet therapy (DAPT) with clopidogrel after percutaneous coronary intervention (PCI), cardiovascular events actually occur in some patients, probably due to dysfunction of genetic cytochrome P450 2C19 (CYP2C19), which is the major metabolic enzymes clopidogrel. As a test to predict patient’s CYP2C19 phenotypes may be less flexibility common in everyday clinical practice, the purpose of this study was to test whether the measured levels of several cytokines in patients presenting with Prus desired in DAPT with clopidogrel can be a substitute for testing CYP2C19 phenotypes.


Methods: We analyzed the relationship between the PRU, serum levels of 51 cytokines and CYP2C19 phenotypes in 22 patients receiving DAPT with aspirin and clopidogrel after PCI.


Results: Seventeen, 18, and 19 of 22 patients showed PRU ≤ 208, 230 ≤ PRU and PRU ≤ 262, respectively. Approximately 60% of patients have a dysfunction of genetic metabolism of CYP2C19, and serum levels of interleukin-18 independently increased in patients (p = 0.024 for patients with PRU ≤ 208, p = 0.021 by PRU ≤ 230, and p = 0.020 by PRU ≤ 262) , Area under the curve in the plot receiver operating characteristic curve for serum levels of interleukin-18 was 0.94, 0.96, and 0.90 in the non-extensive metabolizer patients with PRU ≤ 208, 230 ≤ PRU and PRU ≤ 262, respectively -masing.


Conclusion: Serum levels of interleukin-18 may be a predictor for diagnosing patients receiving DAPT unwanted by clopidogrel, CYP2C19 may be due to genetic dysfunction regardless of the P2Y12 reaction fits after PCI.

Serum interleukin-18 levels as a predictor for patients with genetic dysfunction of cytochrome P450 2C19 in dual antiplatelet therapy with clopidogrel
Serum interleukin-18 levels as a predictor for patients with genetic dysfunction of cytochrome P450 2C19 in dual antiplatelet therapy with clopidogrel

Genetic alteration of interleukin-17 and related genes in human prostate cancer.

Interleukin-17 (IL-17) has been shown to promote the development of hormone-naive prostate cancer (HNPC) and castration-resistant prostate cancer (CRPC) and lymph node metastasis in mouse models. changes in the gene IL-17 family of cytokines and their downstream genes in human prostate cancer has not been investigated. We studied 7 dataset archived at cBioPortal and ask gene changes in a total of 1303 cases of human prostate cancer. 35 genes examined, including IL-17 family of cytokines and receptors, IL-17 gene-downstream, and genes associated with IL-17 gene-downstream.

We found that 34/35 (97%) genes have a more significant change in metastatic prostate cancer (the rate of change ranging from 3.42% to 13.01%) of primary prostate cancer (the rate of change ranging from 0.40% to 2.96%). 15/35 (43%) genes have a more significant change in the prime of HNPC primary CRPC. 34/35 (97%) genes have a more significant change in CRPC metastases from primary HNPC. Only three genes (S100A7, S100A8 and S100A9) have a more significant change in CRPC metastases from CRPC primer.

Interleukin II (60-70)

A1030-25 25 mg
EUR 456
Description: Interleukin II (60-70), (C68H104N14O14S), is a peptide with the sequence NH2- LEU-THR-PHE-LYS-PHE-TYR-MET-PRO-LYS-LYS-ALA-COOH, MW= 1373.7.

Interleukin II (60-70)

A1030-5 5 mg
EUR 224
Description: Interleukin II (60-70), (C68H104N14O14S), is a peptide with the sequence NH2- LEU-THR-PHE-LYS-PHE-TYR-MET-PRO-LYS-LYS-ALA-COOH, MW= 1373.7.

Interleukin II (60-70)

5-01401 4 x 5mg Ask for price

Rapamycin, 10mg

R5312-10mg
EUR 204

Doxorubicin HCl, 10mg

R2531-10mg
EUR 197

IL2 (60-70) Peptide

20-abx266260
  • EUR 467.00
  • EUR 759.00
  • EUR 342.00
  • 10 mg
  • 25 mg
  • 5 mg
  • Shipped within 5-10 working days.

Goat Anti-Mouse IgG Fc, 10MG

A008-10MG 10MG
EUR 268

Goat Anti-Rabbit IgG Fc, 10MG

A009-10MG 10MG
EUR 268

Recombinant other Alarelin Protein, Untagged, -10mg

QP10997-10mg 10mg
EUR 201

Bay 60-7550

GN2518-10MG 10 mg
EUR 907

Human Kinase Library II

HKIN-II 1 set
EUR 450

Human Drug Detoxication II

HDTX-II 1 set
EUR 645

Magnetic Beads (DNA) 60 mL

P920-60 NULL
EUR 0

Bridge-It cAMP-PDE 60

PD1016-60 1 Kit
EUR 266

Donkey Anti-Sheep IgG (H&L), 10MG

A010-10MG 10MG
EUR 268

Recombinant Human EDN3 Protein, Untagged, E.coli-10mg

QP11747-10mg 10mg
EUR 2349

Recombinant other Exenatide Protein, Untagged, E.coli-10mg

QP11816-10mg 10mg
EUR 962

Recombinant E.coli LACTB Protein, Untagged, E.coli-10mg

QP12522-10mg 10mg
EUR 962

Recombinant other Lanreotide Protein, Untagged, E.coli-10mg

QP12536-10mg 10mg
EUR 563

Recombinant Human LHRH Protein, Untagged, E.coli-10mg

QP12569-10mg 10mg
EUR 155

Recombinant other protein 1, Untagged, E.coli-10mg

QP13162-10mg 10mg
EUR 201

Recombinant Human Leptin Protein, Untagged, E.coli-10mg

QP5350-10mg 10mg
EUR 509

Recombinant Mouse Leptin Protein, Untagged, E.coli-10mg

QP5429-10mg 10mg
EUR 962

Recombinant Rat Leptin Protein, Untagged, E.coli-10mg

QP5507-10mg 10mg
EUR 916

Recombinant Human Insulin Protein, Untagged, E.coli-10mg

QP10732-10mg 10mg
EUR 201

Recombinant other Lysostaphin Protein, Untagged, E.coli-10mg

QP10778-10mg 10mg
EUR 418

Recombinant Multi Species ACTH Protein, Untagged, -10mg

QP10950-10mg 10mg
EUR 201

Recombinant other Atosiban Protein, Untagged, E.coli-10mg

QP11102-10mg 10mg
EUR 155

Recombinant other Cetrorelix Protein, Untagged, E.coli-10mg

QP11394-10mg 10mg
EUR 862

Recombinant other SPA Protein, His, E.coli-10mg

QP13566-10mg 10mg
EUR 155

Recombinant other SST Protein, Untagged, E.coli-10mg

QP13598-10mg 10mg
EUR 201

Recombinant Rabbit TNC Protein, Untagged, Rabbit-10mg

QP13765-10mg 10mg
EUR 1061

Recombinant other Avidin Biotin Protein, Untagged, -10mg

QP10526-10mg 10mg
EUR 201

Recombinant Human CTRB1 Protein, Untagged, E.coli-10mg

QP10565-10mg 10mg
EUR 201

Human Cytokine Primer Library II

HCA-II 1 set
EUR 450

Mouse Cytokine Primer Library II

MCA-II 1 set
EUR 450

Rat Cytokine Primer Library II

RCA-II 1 set
EUR 548

Recombinant Human Ferritin Protein, Untagged, Native Protein-10mg

QP11867-10mg 10mg
EUR 2158

Recombinant Bovine Fibronectin Protein, Untagged, Native Protein-10mg

QP11880-10mg 10mg
EUR 1017

Recombinant Human Fibronectin Protein, Untagged, Native Protein-10mg

QP11881-10mg 10mg
EUR 1017

Recombinant Human Haptoglobin Protein, Untagged, Native Protein-10mg

QP12103-10mg 10mg
EUR 1959

Recombinant Human HbA1c Protein, Untagged, Native Protein-10mg

QP12117-10mg 10mg
EUR 2259

Recombinant Human HDL Protein, Untagged, Native Protein-10mg

QP12211-10mg 10mg
EUR 201

Recombinant other HSA Protein, Untagged, Pichia Pastoris-10mg

QP12314-10mg 10mg
EUR 155

Recombinant other HSA Recombinant Protein, Untagged, Rice-10mg

QP12317-10mg 10mg
EUR 163

Recombinant Human LDL Protein, Untagged, Native Protein-10mg

QP12550-10mg 10mg
EUR 163

Recombinant Human LTF Protein, Untagged, Native Protein-10mg

QP12595-10mg 10mg
EUR 4851

Recombinant Human LTF Holo Protein, Untagged, Rice-10mg

QP12596-10mg 10mg
EUR 155

Recombinant Human Myoglobin Protein, Untagged, Native Protein-10mg

QP12776-10mg 10mg
EUR 2059

Recombinant other Protein-L Protein, Untagged, E.coli-10mg

QP13168-10mg 10mg
EUR 201

Recombinant other Lipase A Protein, Untagged, E.coli-10mg

QP10772-10mg 10mg
EUR 155

Recombinant Human MG Protein, Untagged, Native Protein-10mg

QP10785-10mg 10mg
EUR 490

Recombinant Bovine Trypsin Protein, Untagged, Native Protein-10mg

QP10896-10mg 10mg
EUR 201

Recombinant Human UTI Protein, Untagged, Native Protein-10mg

QP10909-10mg 10mg
EUR 209

Recombinant Human A2M Protein, Untagged, Native Protein-10mg

QP10922-10mg 10mg
EUR 1624

Recombinant Human APOB Protein, Untagged, Native Protein-10mg

QP11047-10mg 10mg
EUR 4553

Recombinant Human B2M Protein, Untagged, Native Protein-10mg

QP11117-10mg 10mg
EUR 1415

Recombinant Human C1q Protein, Untagged, Native Protein-10mg

QP11228-10mg 10mg
EUR 4553

Recombinant Human C3c Protein, Untagged, Native Protein-10mg

QP11238-10mg 10mg
EUR 1161

Recombinant Human C4c Protein, Untagged, Native Protein-10mg

QP11240-10mg 10mg
EUR 3556

Recombinant Human CKM Protein, Untagged, Native Protein-10mg

QP11436-10mg 10mg
EUR 4806

Recombinant Human CRP Protein, Untagged, Native Protein-10mg

QP11511-10mg 10mg
EUR 916

Recombinant other SPA 33.4kDa Protein, Untagged, E.coli-10mg

QP13567-10mg 10mg
EUR 155

Recombinant other SPA Long Protein, Untagged, E.coli-10mg

QP13568-10mg 10mg
EUR 155

Recombinant other SPA-Cys Protein, Untagged, E.coli-10mg

QP13569-10mg 10mg
EUR 155

Recombinant other Streptavidin Protein, Untagged, Native Protein-10mg

QP13625-10mg 10mg
EUR 201

Recombinant Multi Species Trp Protein, Untagged, E.coli-10mg

QP13821-10mg 10mg
EUR 245

Recombinant other hCG Protein, Untagged, Native Protein-10mg

QP10664-10mg 10mg
EUR 245

Human Colon Cancer Primer Library II

HCCP-II 1 set
EUR 548

Human DNA Repair Primer Library II

HDRL-II 1 set
EUR 548

Mouse DNA Repair Primer Library II

MDRL-II 1 set
EUR 645

Human Interferon Type II Signaling Primer Library

HIFN-II 1 set
EUR 548

Human Cancer Driver Gene II Primer Library

HCDG-II 1 set
EUR 645

DiagNano Fluorophore Labeled Gold Nanoparticles, 60 nm

GFL-60 1 mL
EUR 1053

Recombinant other HSA Lipid free Protein, Untagged, Rice-10mg

QP12316-10mg 10mg
EUR 163

Recombinant other Protein-A/G Protein, His, E.coli-10mg

QP13163-10mg 10mg
EUR 201

Recombinant other Protein-G His Protein, His, E.coli-10mg

QP13167-10mg 10mg
EUR 318

Recombinant other Protein-L Cys Protein, Untagged, E.coli-10mg

QP13169-10mg 10mg
EUR 201

Recombinant Human Collagen-III Protein, Untagged, Pichia Pastoris-10mg

QP11479-10mg 10mg
EUR 281

Recombinant other Cys-Protein-G Protein, Untagged, E.coli-10mg

QP11587-10mg 10mg
EUR 318

Recombinant other Cys-Protein-L Protein, Untagged, E.coli-10mg

QP11588-10mg 10mg
EUR 201

Recombinant other SPA-Cys His Protein, His, E.coli-10mg

QP13570-10mg 10mg
EUR 155

Recombinant other SPA-Cys Long Protein, Untagged, E.coli-10mg

QP13571-10mg 10mg
EUR 155

Angiotensin II antibody

70-1089 100 ug
EUR 727
Description: Rabbit anti-human Angiotensin II antibody

Recombinant other protein 1, Untagged, E.coli-10mg

QP10853-EC-10mg 10mg
EUR 155

DiagNano Gold Nanoparticle Passive Conjugation Kit, 60 nm

GPK-60 1 kit
EUR 715

Recombinant other Protein Cys-A/G Protein, Untagged, E.coli-10mg

QP13161-10mg 10mg
EUR 201

Recombinant other Protein-A/G Cys Protein, Untagged, E.coli-10mg

QP13164-10mg 10mg
EUR 201

Recombinant other Protein-A/G/L Protein, Untagged, E.coli-10mg

QP13165-10mg 10mg
EUR 327

Recombinant Human GH1/ Growth hormone 1 Protein, Untagged, E.coli-10mg

QP5354-10mg 10mg
EUR 1243

DiagNano Fluorophore Labeled Gold Nanoparticles, 70 nm

GFL-70 1 mL
EUR 1053

Acc II unit: 70

YRACC2 1 vial Ask for price

Hae II unit: 70

YRHAE2 1 vial Ask for price

Recombinant other Protein-A/G/L-Cys Protein, Untagged, E.coli-10mg

QP13166-10mg 10mg
EUR 327

Recombinant other Cys-Protein-A/G/L Protein, Untagged, E.coli-10mg

QP11586-10mg 10mg
EUR 327

Interleukin II (60-70) (AA: Leu-Thr-Phe-Lys-Phe-Tyr-Met-Pro-Lys-Lys-Ala) (MW: 1373.74)

SP-88517-5 5 mg
EUR 286

DiagNano Gold Nanoparticle Passive Conjugation Kit, 70 nm

GPK-70 1 kit
EUR 715

CORNING®60 X 15 MM PETRI DISH WITH COVER

70165-60 12/pk
EUR 119
Description: Vista Petri Dishes; PYREX VISTA Petri Dishes

De-Plasma™ II

D030-10MG 10 mg
EUR 152

DiagNano Gold Nanoparticle Medium Covalent Conjugation Kit, 60 nm

GCK-M-60 1 kit
EUR 757

DiagNano Gold Nanoparticle Medium Covalent Conjugation Kit, 70 nm

GCK-M-70 1 kit
EUR 757

Biotin-DHPE: (10mg)

60022 10MG
EUR 237
Description: Minimum order quantity: 1 unit of 10MG

Cellmaxin, 10mg/ml

C3314-006 6x1ml
EUR 212

Cellmaxin, 10mg/ml

C3314-020 20ml
EUR 327

?-Interleukin II (44-56)

A1027-10 10 mg
EUR 166
Description: ?-Interleukin II (44-56), (C68H113N19O19) is a peptide with the sequence NH2-ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU-COOH, MW= 1500.7.

?-Interleukin II (44-56)

A1027-25 25 mg
EUR 212
Description: ?-Interleukin II (44-56), (C68H113N19O19) is a peptide with the sequence NH2-ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU-COOH, MW= 1500.7.

?-Interleukin II (44-56)

A1027-5 5 mg
EUR 119
Description: ?-Interleukin II (44-56), (C68H113N19O19) is a peptide with the sequence NH2-ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU-COOH, MW= 1500.7.

Custom Peptide Synthesis (>70% antigen grade; mass spec, hplc (mg-kg size, price based upon peptide size: 2-100 aa)

PEP-70 1 Ask for price

Hydroxystilbamidine (Fluoro-Gold): (10mg)

80014 10MG
EUR 253
Description: Minimum order quantity: 1 unit of 10MG

Transferrin Solution, 10mg/ml

CA205-005 5x1ml
EUR 115

beta-Interleukin II (44-56)

5-00494 4 x 5mg Ask for price

Chicken Interleukin 12, IL-12/70 ELISA Kit

CSB-E12836C-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativecompetitive ELISA kit for measuring Chicken Interleukin 12, IL-12/70 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Chicken Interleukin 12, IL-12/70 ELISA Kit

1-CSB-E12836C
  • EUR 878.00
  • EUR 5475.00
  • EUR 2900.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativecompetitive ELISA kit for measuring Chicken Interleukin 12, IL-12/70 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Recombinant Echinococcus Granulosus CaBP-II Protein (aa 1-70)

VAng-Ly4000-1mgEcoli 1 mg (E. coli)
EUR 2675
Description: Echinococcus Granulosus calcium-binding protein 2 (CaBP-II), recombination protein.

Recombinant Echinococcus Granulosus CaBP-II Protein (aa 1-70)

VAng-Ly4000-500gEcoli 500 µg (E. coli)
EUR 1906
Description: Echinococcus Granulosus calcium-binding protein 2 (CaBP-II), recombination protein.

Recombinant Echinococcus Granulosus CaBP-II Protein (aa 1-70)

VAng-Ly4000-50gEcoli 50 µg (E. coli)
EUR 1315
Description: Echinococcus Granulosus calcium-binding protein 2 (CaBP-II), recombination protein.

Dihydrorhodamine 123, dihydrochloride salt: (10mg)

10056 10MG
EUR 191
Description: Minimum order quantity: 1 unit of 10MG

DAPI, 10mg/mL in H2O

40043 1ML
EUR 134
Description: Minimum order quantity: 1 unit of 1ML

RNase A Solution (10mg/ml)

RB0474 1ml
EUR 55.22
  • Product category: Proteins/Enzymes/Endonucleases

ZP(Anti-Zona Pellucida Antibody IgA) ELISA test

70 96T/Box Ask for price
  • Area of application: Immunological infertility
Description: ELISA based test for quantitative detection of ZP(Anti-Zona Pellucida Antibody IgA)

beta Interleukin II (44-56) Peptide

20-abx266398
  • EUR 523.00
  • EUR 871.00
  • EUR 384.00
  • 10 mg
  • 25 mg
  • 5 mg
  • Shipped within 5-10 working days.

ACA (Anticardiolipin Antibody IgM) ELISA test

60 96T/Box Ask for price
  • Area of application: Immunological infertility
Description: ELISA based test for quantitative detection of ACA (Anticardiolipin Antibody IgM)

HL-60

C0003023 One Frozen vial
EUR 485

Tween 60

GL6809-100ML 100 ml
EUR 44

Tween 60

GL6809-1L 1 l
EUR 86

Tween 60

GL6809-500ML 500 ml
EUR 62

hSP-60/ Rat hSP- 60 ELISA Kit

ELA-E0822r 96 Tests
EUR 886

Aligner 13-24

KS072012-II 1 Kit
EUR 412
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

RapidSeq High Yield Directional mRNA Sample Prep Kit - With Aligner 13-24

KS073012-II 1 Kit
EUR 1142
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

RapidSeq High Yield Small RNA Sample Prep Kit - With Aligner 13-24

KS074012-II 1 Kit
EUR 1021
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Attoglow Western Blot Analysis Kit- with Millennium Enhancer, Anti rabbit secondary antibody

K3171120-II 1200 cm2
EUR 246
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Attoglow Western Blot Analysis Kit- with Millennium Enhancer, Anti rabbit secondary antibody

K3171250-II 2500 cm2
EUR 310
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

CORNING® COLLAGEN I, HUMAN, 10MG

354265 1/pk
EUR 348
Description: Advanced Cells - DL; ECM - DL

5-Carboxy-2', 7'-dichlorosulfonefluorescein:(10mg)

51023 10MG
EUR 204
Description: Minimum order quantity: 1 unit of 10MG

Acridine Orange, 10mg/mL in water

40039 10ML
EUR 101
Description: Minimum order quantity: 1 unit of 10ML

Hoechst 33258, 10mg/mL in H2O

40044 10ML
EUR 217
Description: Minimum order quantity: 1 unit of 10ML

Hoechst 33342, 10mg/mL in H2O

40046 10ML
EUR 232
Description: Minimum order quantity: 1 unit of 10ML

Ethidium Bromide, 10mg/ml Stock Solution

E0205-001 10ml
EUR 88

Ethidium Bromide, 10mg/ml Stock Solution

E0205-002 20ml
EUR 128

Ethidium bromide, 10mg/ml in water

GT9211-10ML 10 ml
EUR 70

Interleukin 1 Receptor Type II (IL1R2) Antibody

20-abx177068
  • EUR 1107.00
  • EUR 537.00
  • 1 mg
  • 200 ug
  • Please enquire.

Interleukin 1 Receptor Type II (IL1R2) Antibody

20-abx177069
  • EUR 1135.00
  • EUR 551.00
  • 1 mg
  • 200 ug
  • Please enquire.

Interleukin 1 Receptor Type II (IL1R2) Antibody

20-abx177070
  • EUR 1135.00
  • EUR 551.00
  • 1 mg
  • 200 ug
  • Please enquire.

The changes in gene amplification most genes (97%), whereas the gene deletion, missense mutations, and truncating mutations are very rare. 7/35 (20%) genes have a more significant change in the primary neuroendocrine prostate cancer (NEPC) of primary adenocarcinoma (AC). 23/35 (66%) genes have a more significant change in NEPC metastasis of AC metastasis. Only three genes (S100A7, S100A8 and S100A9) have a more significant change in NEPC metastasis of AC metastases with neuroendocrine features. Most of the changes in NEPC metastasis gene is a gene amplification (80%), whereas the gene deletion, missense mutations, and truncating mutations are very rare.

Djoumana

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