Background: P2Y12 Reaction Units (PRU) is an index of platelet activity after treatment with clopidogrel. Apart from the reactions of the P2Y12 fit in dual antiplatelet therapy (DAPT) with clopidogrel after percutaneous coronary intervention (PCI), cardiovascular events actually occur in some patients, probably due to dysfunction of genetic cytochrome P450 2C19 (CYP2C19), which is the major metabolic enzymes clopidogrel. As a test to predict patient’s CYP2C19 phenotypes may be less flexibility common in everyday clinical practice, the purpose of this study was to test whether the measured levels of several cytokines in patients presenting with Prus desired in DAPT with clopidogrel can be a substitute for testing CYP2C19 phenotypes.
Methods: We analyzed the relationship between the PRU, serum levels of 51 cytokines and CYP2C19 phenotypes in 22 patients receiving DAPT with aspirin and clopidogrel after PCI.
Results: Seventeen, 18, and 19 of 22 patients showed PRU ≤ 208, 230 ≤ PRU and PRU ≤ 262, respectively. Approximately 60% of patients have a dysfunction of genetic metabolism of CYP2C19, and serum levels of interleukin-18 independently increased in patients (p = 0.024 for patients with PRU ≤ 208, p = 0.021 by PRU ≤ 230, and p = 0.020 by PRU ≤ 262) , Area under the curve in the plot receiver operating characteristic curve for serum levels of interleukin-18 was 0.94, 0.96, and 0.90 in the non-extensive metabolizer patients with PRU ≤ 208, 230 ≤ PRU and PRU ≤ 262, respectively -masing.
Conclusion: Serum levels of interleukin-18 may be a predictor for diagnosing patients receiving DAPT unwanted by clopidogrel, CYP2C19 may be due to genetic dysfunction regardless of the P2Y12 reaction fits after PCI.
Serum interleukin-18 levels as a predictor for patients with genetic dysfunction of cytochrome P450 2C19 in dual antiplatelet therapy with clopidogrel
Genetic alteration of interleukin-17 and related genes in human prostate cancer.
Interleukin-17 (IL-17) has been shown to promote the development of hormone-naive prostate cancer (HNPC) and castration-resistant prostate cancer (CRPC) and lymph node metastasis in mouse models. changes in the gene IL-17 family of cytokines and their downstream genes in human prostate cancer has not been investigated. We studied 7 dataset archived at cBioPortal and ask gene changes in a total of 1303 cases of human prostate cancer. 35 genes examined, including IL-17 family of cytokines and receptors, IL-17 gene-downstream, and genes associated with IL-17 gene-downstream.
We found that 34/35 (97%) genes have a more significant change in metastatic prostate cancer (the rate of change ranging from 3.42% to 13.01%) of primary prostate cancer (the rate of change ranging from 0.40% to 2.96%). 15/35 (43%) genes have a more significant change in the prime of HNPC primary CRPC. 34/35 (97%) genes have a more significant change in CRPC metastases from primary HNPC. Only three genes (S100A7, S100A8 and S100A9) have a more significant change in CRPC metastases from CRPC primer.
Description: ?-Interleukin II (44-56), (C68H113N19O19) is a peptide with the sequence NH2-ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU-COOH, MW= 1500.7.
Description: ?-Interleukin II (44-56), (C68H113N19O19) is a peptide with the sequence NH2-ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU-COOH, MW= 1500.7.
Description: ?-Interleukin II (44-56), (C68H113N19O19) is a peptide with the sequence NH2-ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU-COOH, MW= 1500.7.
Description: Quantitativecompetitive ELISA kit for measuring Chicken Interleukin 12, IL-12/70 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Description: Quantitativecompetitive ELISA kit for measuring Chicken Interleukin 12, IL-12/70 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
Description: A sandwich ELISA for quantitative measurement of Porcine Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Porcine Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Porcine Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Canine Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Canine Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Canine Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Rat Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Rat Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Rat Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat Interleukin 1 Receptor Type II (IL1R2) Protein
Description: A sandwich ELISA for quantitative measurement of Goat Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Goat Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Goat Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Interleukin 1 Receptor Type II (IL1R2) Protein
Description: A sandwich ELISA for quantitative measurement of Rabbit Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Soluble interleukin 1 receptor II ELISA kit
Description: A sandwich ELISA for quantitative measurement of Rabbit Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Soluble interleukin 1 receptor II ELISA kit
Description: A sandwich ELISA for quantitative measurement of Rabbit Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Soluble interleukin 1 receptor II ELISA kit
Description: A sandwich ELISA for quantitative measurement of Monkey Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Soluble interleukin 1 receptor II ELISA kit
Description: A sandwich ELISA for quantitative measurement of Monkey Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Soluble interleukin 1 receptor II ELISA kit
Description: A sandwich ELISA for quantitative measurement of Monkey Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Interleukin 1 Receptor Type II (IL1R2) Protein
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 1 Receptor Type II (IL1R2) in samples from serum, plasma, tissue homogenates or other biological fluids.
Human Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 1 Receptor Type II (IL1R2) in samples from serum, plasma, tissue homogenates or other biological fluids.
Mouse Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 1 Receptor Type II (IL1R2) in samples from serum, plasma, tissue homogenates or other biological fluids.
Mouse Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 1 Receptor Type II (IL1R2) in samples from serum, plasma, tissue homogenates or other biological fluids.
Human IL1R2(Interleukin 1 Receptor Type II) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interleukin 1 Receptor Type II (IL1R2) in serum, plasma, tissue homogenates and other biological fluids.
Human Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interleukin 1 Receptor Type II (IL1R2) in serum, plasma, tissue homogenates and other biological fluids.
Human Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interleukin 1 Receptor Type II (IL1R2) in serum, plasma, tissue homogenates and other biological fluids.
Human Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interleukin 1 Receptor Type II (IL1R2) in serum, plasma, tissue homogenates and other biological fluids.
Human Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Interleukin 1 Receptor Type II (IL1R2) in samples from Serum, plasma, tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.
Mouse Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 1 Receptor Type II (IL1R2) in serum, plasma, tissue homogenates and other biological fluids.
Mouse Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 1 Receptor Type II (IL1R2) in serum, plasma, tissue homogenates and other biological fluids.
Mouse Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 1 Receptor Type II (IL1R2) in serum, plasma, tissue homogenates and other biological fluids.
Mouse Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 1 Receptor Type II (IL1R2) in serum, plasma, tissue homogenates and other biological fluids.
Mouse Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Interleukin 1 Receptor Type II (IL1R2) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species.
Rabbit Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Monkey Interleukin 1 Receptor Type II (IL1R2) in samples from serum, plasma or other biological fluids.
Monkey Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Monkey Interleukin 1 Receptor Type II (IL1R2) in samples from serum, plasma or other biological fluids.
Monkey Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Simian Interleukin 1 Receptor Type II (IL1R2) in serum, plasma and other biological fluids.
Simian Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Simian Interleukin 1 Receptor Type II (IL1R2) in serum, plasma and other biological fluids.
Simian Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Simian Interleukin 1 Receptor Type II (IL1R2) in serum, plasma and other biological fluids.
Simian Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Simian Interleukin 1 Receptor Type II (IL1R2) in serum, plasma and other biological fluids.
Simian Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Simian Interleukin 1 Receptor Type II (IL1R2) in samples from Serum, plasma and other biological fluids. with no significant corss-reactivity with analogues from other species.
Chicken Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: A sandwich ELISA for quantitative measurement of Guinea pig Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Guinea pig Soluble interleukin 1 receptor II ELISA kit
Description: A sandwich ELISA for quantitative measurement of Guinea pig Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Guinea pig Soluble interleukin 1 receptor II ELISA kit
Description: A sandwich ELISA for quantitative measurement of Guinea pig Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat Soluble Interleukin-1 Receptor II (IL-1SRII) CLIA Kit
Description: A sandwich ELISA kit for detection of Interleukin 1 Receptor Type II from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
ELISA kit for Human IL1R2 (Interleukin 1 Receptor Type II)
Description: A sandwich ELISA kit for detection of Interleukin 1 Receptor Type II from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
Rat soluble interleukin- 1 receptor II, IL- 3sRII ELISA kit
Description: A sandwich ELISA kit for detection of Interleukin 1 Receptor Type II from Simian in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
Human soluble interleukin- 1 receptor II, IL- 1sRII ELISA kit
Description: A sandwich CLIA kit for quantitative measurement of Human IL-1R2 (Interleukin 1 Receptor Type II) in samples from Serum, Plasma, Cell supernatant
Description: Recombinant Human Interleukin-10 is a disulfide-linked monomer protein consisting of 161 amino acid residues, and migrates as an approximately 19 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human Interleukin-10 mature chain was expressed in E. coli.
Description: Recombinant Human Interleukin-10 is a disulfide-linked monomer protein consisting of 161 amino acid residues, and migrates as an approximately 19 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human Interleukin-10 mature chain was expressed in E. coli.
Description: Recombinant Mouse IL-10 is a disulfide-linked monomer protein consisting of 161 amino acid residues, and migrates as an approximately 19 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding mouse Interleukin-10 mature chain was expressed in E. coli.
Description: Recombinant Mouse IL-10 is a disulfide-linked monomer protein consisting of 161 amino acid residues, and migrates as an approximately 19 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding mouse Interleukin-10 mature chain was expressed in E. coli.
Description: Recombinant IL-11 is a disulfide-linked monomer protein consisting of 179 amino acid residues, and migrates as an approximately 19 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human Interleukin-11 mature chain was expressed in E. coli.
Description: Recombinant IL-11 is a disulfide-linked monomer protein consisting of 179 amino acid residues, and migrates as an approximately 19 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human Interleukin-11 mature chain was expressed in E. coli.
Description: Recombinant IL-11 is a disulfide-linked monomer protein consisting of 179 amino acid residues, and migrates as an approximately 19 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding mouse Interleukin-11 mature chain was expressed in E. coli.
Description: Recombinant IL-11 is a disulfide-linked monomer protein consisting of 179 amino acid residues, and migrates as an approximately 19 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding mouse Interleukin-11 mature chain was expressed in E. coli.
Description: Recombinant Interleukin-12 is a disulfide-linked heterpdimer protein consisting of 306 amino acid residue p40 subunit and a 197 amino acid residue p35 subunit, and migrates due to glycosylation as an approximately 75 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human Interleukin-12 mature chain was expressed in Chinese Hamster Ovary (CHO) cells.
Description: Recombinant Interleukin-12 is a disulfide-linked heterpdimer protein consisting of 306 amino acid residue p40 subunit and a 197 amino acid residue p35 subunit, and migrates due to glycosylation as an approximately 75 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human Interleukin-12 mature chain was expressed in Chinese Hamster Ovary (CHO) cells.
Description: Recombinant IL-13 is a disulfide-linked monomer protein consisting of 115 amino acid residues,and migrates as an approximately 13 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human Interleukin-13 mature chain was expressed in E. coli.
Description: Recombinant IL-13 is a disulfide-linked monomer protein consisting of 115 amino acid residues,and migrates as an approximately 13 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human Interleukin-13 mature chain was expressed in E. coli.
Description: Recombinant Interleukin-15 is a disulfide-linked homodimeric protein consisting of two 115 amino acid residues, and migrates as an approximately 13 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human Interleukin-15 mature chain was expressed in E. coli.
Description: Recombinant Interleukin-15 is a disulfide-linked homodimeric protein consisting of two 115 amino acid residues, and migrates as an approximately 13 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human Interleukin-15 mature chain was expressed in E. coli.
Description: Recombinant Interleukin-18 is a disulfide-linked monomer protein consisting of 158 amino acid residues, migrates as an approximately 18 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human Interleukin-18 mature chain was expressed in E. coli.
Description: Recombinant Interleukin-18 is a disulfide-linked monomer protein consisting of 158 amino acid residues, migrates as an approximately 18 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human Interleukin-18 mature chain was expressed in E. coli.
Description: Recombinant IL-21 is a disulfide-linked homodimeric protein consisting of 132 amino acid residues, and migrates as an approximately 15 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding murine Interleukin-21 mature chain was expressed in E. coli.
Description: Recombinant IL-21 is a disulfide-linked homodimeric protein consisting of 132 amino acid residues, and migrates as an approximately 15 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding murine Interleukin-21 mature chain was expressed in E. coli.
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The changes in gene amplification most genes (97%), whereas the gene deletion, missense mutations, and truncating mutations are very rare. 7/35 (20%) genes have a more significant change in the primary neuroendocrine prostate cancer (NEPC) of primary adenocarcinoma (AC). 23/35 (66%) genes have a more significant change in NEPC metastasis of AC metastasis. Only three genes (S100A7, S100A8 and S100A9) have a more significant change in NEPC metastasis of AC metastases with neuroendocrine features. Most of the changes in NEPC metastasis gene is a gene amplification (80%), whereas the gene deletion, missense mutations, and truncating mutations are very rare.
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