Serum interleukin-18 levels as a predictor for patients with genetic dysfunction of cytochrome P450 2C19 in dual antiplatelet therapy with clopidogrel

Serum interleukin-18 levels as a predictor for patients with genetic dysfunction of cytochrome P450 2C19 in dual antiplatelet therapy with clopidogrel

Background: P2Y12 Reaction Units (PRU) is an index of platelet activity after treatment with clopidogrel. Apart from the reactions of the P2Y12 fit in dual antiplatelet therapy (DAPT) with clopidogrel after percutaneous coronary intervention (PCI), cardiovascular events actually occur in some patients, probably due to dysfunction of genetic cytochrome P450 2C19 (CYP2C19), which is the major metabolic enzymes clopidogrel. As a test to predict patient’s CYP2C19 phenotypes may be less flexibility common in everyday clinical practice, the purpose of this study was to test whether the measured levels of several cytokines in patients presenting with Prus desired in DAPT with clopidogrel can be a substitute for testing CYP2C19 phenotypes.


Methods: We analyzed the relationship between the PRU, serum levels of 51 cytokines and CYP2C19 phenotypes in 22 patients receiving DAPT with aspirin and clopidogrel after PCI.


Results: Seventeen, 18, and 19 of 22 patients showed PRU ≤ 208, 230 ≤ PRU and PRU ≤ 262, respectively. Approximately 60% of patients have a dysfunction of genetic metabolism of CYP2C19, and serum levels of interleukin-18 independently increased in patients (p = 0.024 for patients with PRU ≤ 208, p = 0.021 by PRU ≤ 230, and p = 0.020 by PRU ≤ 262) , Area under the curve in the plot receiver operating characteristic curve for serum levels of interleukin-18 was 0.94, 0.96, and 0.90 in the non-extensive metabolizer patients with PRU ≤ 208, 230 ≤ PRU and PRU ≤ 262, respectively -masing.


Conclusion: Serum levels of interleukin-18 may be a predictor for diagnosing patients receiving DAPT unwanted by clopidogrel, CYP2C19 may be due to genetic dysfunction regardless of the P2Y12 reaction fits after PCI.

Serum interleukin-18 levels as a predictor for patients with genetic dysfunction of cytochrome P450 2C19 in dual antiplatelet therapy with clopidogrel
Serum interleukin-18 levels as a predictor for patients with genetic dysfunction of cytochrome P450 2C19 in dual antiplatelet therapy with clopidogrel

Genetic alteration of interleukin-17 and related genes in human prostate cancer.

Interleukin-17 (IL-17) has been shown to promote the development of hormone-naive prostate cancer (HNPC) and castration-resistant prostate cancer (CRPC) and lymph node metastasis in mouse models. changes in the gene IL-17 family of cytokines and their downstream genes in human prostate cancer has not been investigated. We studied 7 dataset archived at cBioPortal and ask gene changes in a total of 1303 cases of human prostate cancer. 35 genes examined, including IL-17 family of cytokines and receptors, IL-17 gene-downstream, and genes associated with IL-17 gene-downstream.

We found that 34/35 (97%) genes have a more significant change in metastatic prostate cancer (the rate of change ranging from 3.42% to 13.01%) of primary prostate cancer (the rate of change ranging from 0.40% to 2.96%). 15/35 (43%) genes have a more significant change in the prime of HNPC primary CRPC. 34/35 (97%) genes have a more significant change in CRPC metastases from primary HNPC. Only three genes (S100A7, S100A8 and S100A9) have a more significant change in CRPC metastases from CRPC primer.

Interleukin II (60-70)

5-01401 4 x 5mg Ask for price

IL2 (60-70) Peptide

20-abx266260
  • EUR 560.40
  • EUR 910.80
  • EUR 410.40
  • 10 mg
  • 25 mg
  • 5 mg

Rapamycin, 10mg

R5312-10mg
EUR 244.8

Doxorubicin HCl, 10mg

R2531-10mg
EUR 236.4

Human Drug Detoxication II

HDTX-II 1 set
EUR 774

Human Kinase Library II

HKIN-II 1 set
EUR 540

beta Interleukin II (44-56) Peptide

20-abx266398
  • EUR 627.60
  • EUR 1045.20
  • EUR 460.80
  • 10 mg
  • 25 mg
  • 5 mg

Bay 60-7550

GN2518-10MG 10 mg
EUR 1088.4

Magnetic Beads (DNA) 60 mL

P920-60 - Ask for price

Bridge-It cAMP-PDE 60

PD1016-60 1 Kit
EUR 319.2

Mouse Cytokine Primer Library II

MCA-II 1 set
EUR 540

Human Cytokine Primer Library II

HCA-II 1 set
EUR 540

Rat Cytokine Primer Library II

RCA-II 1 set
EUR 657.6

Goat Anti-Mouse IgG Fc, 10MG

A008-10MG 10MG
EUR 321.6

Goat Anti-Rabbit IgG Fc, 10MG

A009-10MG 10MG
EUR 321.6

Recombinant other Alarelin Protein, Untagged, -10mg

QP10997-10mg 10mg
EUR 241.2

Mouse DNA Repair Primer Library II

MDRL-II 1 set
EUR 774

Human Colon Cancer Primer Library II

HCCP-II 1 set
EUR 657.6

Human DNA Repair Primer Library II

HDRL-II 1 set
EUR 657.6

Donkey Anti-Sheep IgG (H&L), 10MG

A010-10MG 10MG
EUR 321.6

Recombinant other Avidin Biotin Protein, Untagged, -10mg

QP10526-10mg 10mg
EUR 241.2

Recombinant Human CTRB1 Protein, Untagged, E.coli-10mg

QP10565-10mg 10mg
EUR 241.2

Recombinant E.coli LACTB Protein, Untagged, E.coli-10mg

QP12522-10mg 10mg
EUR 1154.4

Recombinant other Lanreotide Protein, Untagged, E.coli-10mg

QP12536-10mg 10mg
EUR 675.6

Recombinant Human LHRH Protein, Untagged, E.coli-10mg

QP12569-10mg 10mg
EUR 186

Recombinant other protein 1, Untagged, E.coli-10mg

QP13162-10mg 10mg
EUR 241.2

Recombinant other SPA Protein, His, E.coli-10mg

QP13566-10mg 10mg
EUR 186

Recombinant other SST Protein, Untagged, E.coli-10mg

QP13598-10mg 10mg
EUR 241.2

Recombinant Rabbit TNC Protein, Untagged, Rabbit-10mg

QP13765-10mg 10mg
EUR 1273.2

Recombinant Human Insulin Protein, Untagged, E.coli-10mg

QP10732-10mg 10mg
EUR 241.2

Recombinant other Lysostaphin Protein, Untagged, E.coli-10mg

QP10778-10mg 10mg
EUR 501.6

Recombinant Multi Species ACTH Protein, Untagged, -10mg

QP10950-10mg 10mg
EUR 241.2

Recombinant other Atosiban Protein, Untagged, E.coli-10mg

QP11102-10mg 10mg
EUR 186

Recombinant Human Leptin Protein, Untagged, E.coli-10mg

QP5350-10mg 10mg
EUR 610.8

Recombinant Mouse Leptin Protein, Untagged, E.coli-10mg

QP5429-10mg 10mg
EUR 1154.4

Recombinant Rat Leptin Protein, Untagged, E.coli-10mg

QP5507-10mg 10mg
EUR 1099.2

Recombinant other Cetrorelix Protein, Untagged, E.coli-10mg

QP11394-10mg 10mg
EUR 1034.4

Recombinant Human EDN3 Protein, Untagged, E.coli-10mg

QP11747-10mg 10mg
EUR 2818.8

Recombinant other Exenatide Protein, Untagged, E.coli-10mg

QP11816-10mg 10mg
EUR 1154.4

Human Cancer Driver Gene II Primer Library

HCDG-II 1 set
EUR 774

Human Interferon Type II Signaling Primer Library

HIFN-II 1 set
EUR 657.6

Anti-Horse Whole Serum | RWS-70

RWS-70 1.0 mL
EUR 130
Description:

Anti-Horse Whole Serum | RWS-70 | Immunology Consultants Laboratory

Host: Rabbit

Format: Whole Serum

Product Type: Primary Antibody

Antibody Clonality: Polyclonal

DiagNano Fluorophore Labeled Gold Nanoparticles, 60 nm

GFL-60 1 mL
EUR 1263.6

Angiotensin II antibody

70-1089 100 ug
EUR 872.4
Description: Rabbit anti-human Angiotensin II antibody

Recombinant Human LDL Protein, Untagged, Native Protein-10mg

QP12550-10mg 10mg
EUR 195.6

Recombinant Human LTF Protein, Untagged, Native Protein-10mg

QP12595-10mg 10mg
EUR 5821.2

Recombinant Human LTF Holo Protein, Untagged, Rice-10mg

QP12596-10mg 10mg
EUR 186

Recombinant Human Myoglobin Protein, Untagged, Native Protein-10mg

QP12776-10mg 10mg
EUR 2470.8

Recombinant other Protein-L Protein, Untagged, E.coli-10mg

QP13168-10mg 10mg
EUR 241.2

Recombinant other SPA 33.4kDa Protein, Untagged, E.coli-10mg

QP13567-10mg 10mg
EUR 186

Recombinant other SPA Long Protein, Untagged, E.coli-10mg

QP13568-10mg 10mg
EUR 186

Recombinant other SPA-Cys Protein, Untagged, E.coli-10mg

QP13569-10mg 10mg
EUR 186

Recombinant other Streptavidin Protein, Untagged, Native Protein-10mg

QP13625-10mg 10mg
EUR 241.2

Recombinant Multi Species Trp Protein, Untagged, E.coli-10mg

QP13821-10mg 10mg
EUR 294

Recombinant other hCG Protein, Untagged, Native Protein-10mg

QP10664-10mg 10mg
EUR 294

Recombinant other Lipase A Protein, Untagged, E.coli-10mg

QP10772-10mg 10mg
EUR 186

Recombinant Human MG Protein, Untagged, Native Protein-10mg

QP10785-10mg 10mg
EUR 588

Recombinant Bovine Trypsin Protein, Untagged, Native Protein-10mg

QP10896-10mg 10mg
EUR 241.2

Recombinant Human UTI Protein, Untagged, Native Protein-10mg

QP10909-10mg 10mg
EUR 250.8

Recombinant Human A2M Protein, Untagged, Native Protein-10mg

QP10922-10mg 10mg
EUR 1948.8

Recombinant Human APOB Protein, Untagged, Native Protein-10mg

QP11047-10mg 10mg
EUR 5463.6

Recombinant Human B2M Protein, Untagged, Native Protein-10mg

QP11117-10mg 10mg
EUR 1698

Recombinant Human C1q Protein, Untagged, Native Protein-10mg

QP11228-10mg 10mg
EUR 5463.6

Recombinant Human C3c Protein, Untagged, Native Protein-10mg

QP11238-10mg 10mg
EUR 1393.2

Recombinant Human C4c Protein, Untagged, Native Protein-10mg

QP11240-10mg 10mg
EUR 4267.2

Recombinant Human CKM Protein, Untagged, Native Protein-10mg

QP11436-10mg 10mg
EUR 5767.2

Recombinant Human CRP Protein, Untagged, Native Protein-10mg

QP11511-10mg 10mg
EUR 1099.2

Recombinant Human Ferritin Protein, Untagged, Native Protein-10mg

QP11867-10mg 10mg
EUR 2589.6

Recombinant Bovine Fibronectin Protein, Untagged, Native Protein-10mg

QP11880-10mg 10mg
EUR 1220.4

Recombinant Human Fibronectin Protein, Untagged, Native Protein-10mg

QP11881-10mg 10mg
EUR 1220.4

Recombinant Human Haptoglobin Protein, Untagged, Native Protein-10mg

QP12103-10mg 10mg
EUR 2350.8

Recombinant Human HbA1c Protein, Untagged, Native Protein-10mg

QP12117-10mg 10mg
EUR 2710.8

Recombinant Human HDL Protein, Untagged, Native Protein-10mg

QP12211-10mg 10mg
EUR 241.2

Recombinant other HSA Protein, Untagged, Pichia Pastoris-10mg

QP12314-10mg 10mg
EUR 186

Recombinant other HSA Recombinant Protein, Untagged, Rice-10mg

QP12317-10mg 10mg
EUR 195.6

DiagNano Fluorophore Labeled Gold Nanoparticles, 70 nm

GFL-70 1 mL
EUR 1263.6

DiagNano Gold Nanoparticle Passive Conjugation Kit, 60 nm

GPK-60 1 kit
EUR 858

Turbidity Std Ratio 60 NTU

CRSR-60-100 100ML
EUR 84.36

Turbidity Std Ratio 60 NTU

CRSR-60-500 500ML
EUR 248.52

Recombinant other Protein-A/G Protein, His, E.coli-10mg

QP13163-10mg 10mg
EUR 241.2

Recombinant other Protein-G His Protein, His, E.coli-10mg

QP13167-10mg 10mg
EUR 381.6

Recombinant other Protein-L Cys Protein, Untagged, E.coli-10mg

QP13169-10mg 10mg
EUR 241.2

Recombinant other SPA-Cys His Protein, His, E.coli-10mg

QP13570-10mg 10mg
EUR 186

Recombinant other SPA-Cys Long Protein, Untagged, E.coli-10mg

QP13571-10mg 10mg
EUR 186

Recombinant Human Collagen-III Protein, Untagged, Pichia Pastoris-10mg

QP11479-10mg 10mg
EUR 337.2

Recombinant other Cys-Protein-G Protein, Untagged, E.coli-10mg

QP11587-10mg 10mg
EUR 381.6

Recombinant other Cys-Protein-L Protein, Untagged, E.coli-10mg

QP11588-10mg 10mg
EUR 241.2

Recombinant other HSA Lipid free Protein, Untagged, Rice-10mg

QP12316-10mg 10mg
EUR 195.6

DiagNano Gold Nanoparticle Passive Conjugation Kit, 70 nm

GPK-70 1 kit
EUR 858

Acc II unit: 70

YRACC2 1 vial Ask for price

Hae II unit: 70

YRHAE2 1 vial Ask for price

Turbidity Std Non Ratio 60 NTU

CRS-60-100 100ML
EUR 118.56

Turbidity Std Non Ratio 60 NTU

CRS-60-500 500ML
EUR 235.98

Interleukin II (60-70) (AA: Leu-Thr-Phe-Lys-Phe-Tyr-Met-Pro-Lys-Lys-Ala) (MW: 1373.74)

SP-88517-5 5 mg
EUR 343.2

Recombinant other Protein Cys-A/G Protein, Untagged, E.coli-10mg

QP13161-10mg 10mg
EUR 241.2

Recombinant other Protein-A/G Cys Protein, Untagged, E.coli-10mg

QP13164-10mg 10mg
EUR 241.2

Recombinant other Protein-A/G/L Protein, Untagged, E.coli-10mg

QP13165-10mg 10mg
EUR 392.4

Recombinant Human GH1/ Growth hormone 1 Protein, Untagged, E.coli-10mg

QP5354-10mg 10mg
EUR 1491.6

Recombinant other protein 1, Untagged, E.coli-10mg

QP10853-EC-10mg 10mg
EUR 186

CORNING®60 X 15 MM PETRI DISH WITH COVER

70165-60 12/pk
EUR 142.8
Description: Vista Petri Dishes; PYREX VISTA Petri Dishes

C3a (70 77) Peptide

20-abx265956
  • EUR 460.80
  • EUR 710.40
  • EUR 360.00
  • 10 mg
  • 25 mg
  • 5 mg

Melanotan II, MT-II Peptide

20-abx265901
  • EUR 444.00
  • EUR 627.60
  • EUR 343.20
  • 10 mg
  • 25 mg
  • 5 mg

Recombinant other Protein-A/G/L-Cys Protein, Untagged, E.coli-10mg

QP13166-10mg 10mg
EUR 392.4

Recombinant other Cys-Protein-A/G/L Protein, Untagged, E.coli-10mg

QP11586-10mg 10mg
EUR 392.4

Uru TK II, Urechistachykinin II Peptide

20-abx266221
  • EUR 560.40
  • EUR 910.80
  • EUR 410.40
  • 10 mg
  • 25 mg
  • 5 mg

De-Plasma™ II

D030-10MG 10 mg
EUR 182.4

Eglin c (60-63)-methyl ester Peptide

20-abx266158
  • EUR 526.80
  • EUR 844.80
  • EUR 393.60
  • 10 mg
  • 25 mg
  • 5 mg

[Ile76]-TNF-a (70-80) Peptide

20-abx265206
  • EUR 560.40
  • EUR 910.80
  • EUR 410.40
  • 10 mg
  • 25 mg
  • 5 mg

Platelet Factor 4 (58-70) Peptide

20-abx265245
  • EUR 627.60
  • EUR 1045.20
  • EUR 460.80
  • 10 mg
  • 25 mg
  • 5 mg

[beta Ala70]-C3a (70-77) Peptide

20-abx266025
  • EUR 477.60
  • EUR 760.80
  • EUR 376.80
  • 10 mg
  • 25 mg
  • 5 mg

DiagNano Gold Nanoparticle Medium Covalent Conjugation Kit, 60 nm

GCK-M-60 1 kit
EUR 908.4

Angiotensin II Peptide

20-abx265094
  • EUR 460.80
  • EUR 710.40
  • EUR 360.00
  • 10 mg
  • 25 mg
  • 5 mg

Angiotensin II Antipeptide

20-abx265974
  • EUR 460.80
  • EUR 710.40
  • EUR 360.00
  • 10 mg
  • 25 mg
  • 5 mg

Leucokinin II Peptide

20-abx266050
  • EUR 493.20
  • EUR 794.40
  • EUR 376.80
  • 10 mg
  • 25 mg
  • 5 mg

Allatostatin II Peptide

20-abx266228
  • EUR 560.40
  • EUR 910.80
  • EUR 410.40
  • 10 mg
  • 25 mg
  • 5 mg

Locustachykinin II Peptide

20-abx266229
  • EUR 560.40
  • EUR 910.80
  • EUR 410.40
  • 10 mg
  • 25 mg
  • 5 mg

DiagNano Gold Nanoparticle Medium Covalent Conjugation Kit, 70 nm

GCK-M-70 1 kit
EUR 908.4

[Val5] Angiotensin II Peptide

20-abx265197
  • EUR 460.80
  • EUR 710.40
  • EUR 360.00
  • 10 mg
  • 25 mg
  • 5 mg

Angiotensin II Substrate Peptide

20-abx265623
  • EUR 560.40
  • EUR 910.80
  • EUR 410.40
  • 10 mg
  • 25 mg
  • 5 mg

He-LWamide II Peptide

20-abx265862
  • EUR 427.20
  • EUR 644.40
  • EUR 343.20
  • 10 mg
  • 25 mg
  • 5 mg

Antho-Rwamide II Peptide

20-abx266022
  • EUR 477.60
  • EUR 760.80
  • EUR 376.80
  • 10 mg
  • 25 mg
  • 5 mg

Ecosafe Universal Filter For FUM7050/60/70/80/90

FUM7092 EACH
EUR 497.04

Entris II Advance Preci Bal 1200g Cap 10mg Read

BAL4546 EACH
EUR 2421.36

Entris II Advance Preci Bal 2200g Cap 10mg Read

BAL4572 EACH
EUR 2661.9

Entris II Advance Preci Bal 3200g Cap 10mg Read

BAL4584 EACH
EUR 2842.02

Entris II Advance Preci Bal 4200g Cap 10mg Read

BAL4594 EACH
EUR 2958.3

Entris II Advance Preci Bal 6200g Cap 10mg Read

BAL4614 EACH
EUR 3717.54

Entris II Advance Preci Bal 820g Cap 10mg Read

BAL4630 EACH
EUR 2340.42

[Fmoc-Glu70,Ala71,72,Lys74]-C3a (70-77) Peptide

20-abx265934
  • EUR 444.00
  • EUR 693.60
  • EUR 343.20
  • 10 mg
  • 25 mg
  • 5 mg

?-Interleukin II (44-56)

A1027-10 10 mg
EUR 199.2
Description: ?-Interleukin II (44-56), (C68H113N19O19) is a peptide with the sequence NH2-ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU-COOH, MW= 1500.7.

?-Interleukin II (44-56)

A1027-25 25 mg
EUR 254.4
Description: ?-Interleukin II (44-56), (C68H113N19O19) is a peptide with the sequence NH2-ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU-COOH, MW= 1500.7.

?-Interleukin II (44-56)

A1027-5 5 mg
EUR 142.8
Description: ?-Interleukin II (44-56), (C68H113N19O19) is a peptide with the sequence NH2-ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU-COOH, MW= 1500.7.

Custom Peptide Synthesis (>70% antigen grade; mass spec, hplc (mg-kg size, price based upon peptide size: 2-100 aa)

PEP-70 1 Ask for price

Angiotensin II (4-8) Peptide

20-abx265182
  • EUR 393.60
  • EUR 594.00
  • EUR 326.40
  • 10 mg
  • 25 mg
  • 5 mg

Angiotensin II (3-8) Peptide

20-abx265183
  • EUR 393.60
  • EUR 594.00
  • EUR 326.40
  • 10 mg
  • 25 mg
  • 5 mg

P60c-src Substrate II Peptide

20-abx265579
  • EUR 427.20
  • EUR 644.40
  • EUR 343.20
  • 10 mg
  • 25 mg
  • 5 mg

Casein Kinase II Substrate Peptide

20-abx265630
  • EUR 526.80
  • EUR 861.60
  • EUR 393.60
  • 10 mg
  • 25 mg
  • 5 mg

IGF-II (33-40) Peptide

20-abx265962
  • EUR 460.80
  • EUR 710.40
  • EUR 360.00
  • 10 mg
  • 25 mg
  • 5 mg

[Asn1,Val5]-Angiotensin II Peptide

20-abx266003
  • EUR 460.80
  • EUR 710.40
  • EUR 360.00
  • 10 mg
  • 25 mg
  • 5 mg

[D-Ala2] Deltorphin II Peptide

20-abx266035
  • EUR 510.00
  • EUR 744.00
  • EUR 376.80
  • 10 mg
  • 25 mg
  • 5 mg

Casein Kinase II Receptor Peptide

20-abx266122
  • EUR 493.20
  • EUR 794.40
  • EUR 376.80
  • 10 mg
  • 25 mg
  • 5 mg

Influenza A NP (366 374) Strain A / NT / 60 / 68 Peptide

20-abx266046
  • EUR 493.20
  • EUR 794.40
  • EUR 376.80
  • 10 mg
  • 25 mg
  • 5 mg

P60c-src Substrate II, Phosphorylated Peptide

20-abx265580
  • EUR 477.60
  • EUR 760.80
  • EUR 376.80
  • 10 mg
  • 25 mg
  • 5 mg

The changes in gene amplification most genes (97%), whereas the gene deletion, missense mutations, and truncating mutations are very rare. 7/35 (20%) genes have a more significant change in the primary neuroendocrine prostate cancer (NEPC) of primary adenocarcinoma (AC). 23/35 (66%) genes have a more significant change in NEPC metastasis of AC metastasis. Only three genes (S100A7, S100A8 and S100A9) have a more significant change in NEPC metastasis of AC metastases with neuroendocrine features. Most of the changes in NEPC metastasis gene is a gene amplification (80%), whereas the gene deletion, missense mutations, and truncating mutations are very rare.

Djoumana

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