Background: P2Y12 Reaction Units (PRU) is an index of platelet activity after treatment with clopidogrel. Apart from the reactions of the P2Y12 fit in dual antiplatelet therapy (DAPT) with clopidogrel after percutaneous coronary intervention (PCI), cardiovascular events actually occur in some patients, probably due to dysfunction of genetic cytochrome P450 2C19 (CYP2C19), which is the major metabolic enzymes clopidogrel. As a test to predict patient’s CYP2C19 phenotypes may be less flexibility common in everyday clinical practice, the purpose of this study was to test whether the measured levels of several cytokines in patients presenting with Prus desired in DAPT with clopidogrel can be a substitute for testing CYP2C19 phenotypes.
Methods: We analyzed the relationship between the PRU, serum levels of 51 cytokines and CYP2C19 phenotypes in 22 patients receiving DAPT with aspirin and clopidogrel after PCI.
Results: Seventeen, 18, and 19 of 22 patients showed PRU ≤ 208, 230 ≤ PRU and PRU ≤ 262, respectively. Approximately 60% of patients have a dysfunction of genetic metabolism of CYP2C19, and serum levels of interleukin-18 independently increased in patients (p = 0.024 for patients with PRU ≤ 208, p = 0.021 by PRU ≤ 230, and p = 0.020 by PRU ≤ 262) , Area under the curve in the plot receiver operating characteristic curve for serum levels of interleukin-18 was 0.94, 0.96, and 0.90 in the non-extensive metabolizer patients with PRU ≤ 208, 230 ≤ PRU and PRU ≤ 262, respectively -masing.
Conclusion: Serum levels of interleukin-18 may be a predictor for diagnosing patients receiving DAPT unwanted by clopidogrel, CYP2C19 may be due to genetic dysfunction regardless of the P2Y12 reaction fits after PCI.
Serum interleukin-18 levels as a predictor for patients with genetic dysfunction of cytochrome P450 2C19 in dual antiplatelet therapy with clopidogrel
Genetic alteration of interleukin-17 and related genes in human prostate cancer.
Interleukin-17 (IL-17) has been shown to promote the development of hormone-naive prostate cancer (HNPC) and castration-resistant prostate cancer (CRPC) and lymph node metastasis in mouse models. changes in the gene IL-17 family of cytokines and their downstream genes in human prostate cancer has not been investigated. We studied 7 dataset archived at cBioPortal and ask gene changes in a total of 1303 cases of human prostate cancer. 35 genes examined, including IL-17 family of cytokines and receptors, IL-17 gene-downstream, and genes associated with IL-17 gene-downstream.
We found that 34/35 (97%) genes have a more significant change in metastatic prostate cancer (the rate of change ranging from 3.42% to 13.01%) of primary prostate cancer (the rate of change ranging from 0.40% to 2.96%). 15/35 (43%) genes have a more significant change in the prime of HNPC primary CRPC. 34/35 (97%) genes have a more significant change in CRPC metastases from primary HNPC. Only three genes (S100A7, S100A8 and S100A9) have a more significant change in CRPC metastases from CRPC primer.
Description: ?-Interleukin II (44-56), (C68H113N19O19) is a peptide with the sequence NH2-ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU-COOH, MW= 1500.7.
Description: ?-Interleukin II (44-56), (C68H113N19O19) is a peptide with the sequence NH2-ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU-COOH, MW= 1500.7.
Description: ?-Interleukin II (44-56), (C68H113N19O19) is a peptide with the sequence NH2-ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU-COOH, MW= 1500.7.
Interleukin II (60-70) (AA: Leu-Thr-Phe-Lys-Phe-Tyr-Met-Pro-Lys-Lys-Ala) (MW: 1373.74)
Description: Quantitativecompetitive ELISA kit for measuring Chicken Interleukin 12, IL-12/70 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Description: Quantitativecompetitive ELISA kit for measuring Chicken Interleukin 12, IL-12/70 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
Description: A sandwich ELISA for quantitative measurement of Porcine Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Porcine Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Porcine Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Canine Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Canine Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Canine Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Rat Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Rat Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Rat Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Goat Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Goat Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Goat Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Rabbit Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Soluble interleukin 1 receptor II ELISA kit
Description: A sandwich ELISA for quantitative measurement of Rabbit Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Soluble interleukin 1 receptor II ELISA kit
Description: A sandwich ELISA for quantitative measurement of Rabbit Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Soluble interleukin 1 receptor II ELISA kit
Description: A sandwich ELISA for quantitative measurement of Monkey Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Soluble interleukin 1 receptor II ELISA kit
Description: A sandwich ELISA for quantitative measurement of Monkey Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Soluble interleukin 1 receptor II ELISA kit
Description: A sandwich ELISA for quantitative measurement of Monkey Soluble interleukin 1 receptor II in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Interleukin 1 Receptor Type II (IL1R2) Protein
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 1 Receptor Type II (IL1R2) in samples from serum, plasma, tissue homogenates or other biological fluids.
Human Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 1 Receptor Type II (IL1R2) in samples from serum, plasma, tissue homogenates or other biological fluids.
Mouse Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 1 Receptor Type II (IL1R2) in samples from serum, plasma, tissue homogenates or other biological fluids.
Mouse Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 1 Receptor Type II (IL1R2) in samples from serum, plasma, tissue homogenates or other biological fluids.
Human IL1R2(Interleukin 1 Receptor Type II) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interleukin 1 Receptor Type II (IL1R2) in serum, plasma, tissue homogenates and other biological fluids.
Human Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interleukin 1 Receptor Type II (IL1R2) in serum, plasma, tissue homogenates and other biological fluids.
Human Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interleukin 1 Receptor Type II (IL1R2) in serum, plasma, tissue homogenates and other biological fluids.
Human Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interleukin 1 Receptor Type II (IL1R2) in serum, plasma, tissue homogenates and other biological fluids.
Human Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Interleukin 1 Receptor Type II (IL1R2) in samples from Serum, plasma, tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.
Mouse Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 1 Receptor Type II (IL1R2) in serum, plasma, tissue homogenates and other biological fluids.
Mouse Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 1 Receptor Type II (IL1R2) in serum, plasma, tissue homogenates and other biological fluids.
Mouse Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 1 Receptor Type II (IL1R2) in serum, plasma, tissue homogenates and other biological fluids.
Mouse Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 1 Receptor Type II (IL1R2) in serum, plasma, tissue homogenates and other biological fluids.
Mouse Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Interleukin 1 Receptor Type II (IL1R2) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species.
Human Interleukin 1 Receptor Type II (IL1R2) ELISA Kit
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human IL1R2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human IL1R2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human IL1R2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human IL1R2 in the samples is then determined by comparing the OD of the samples to the standard curve.
Human IL1R2(Interleukin 1 Receptor Type II) ELISA Kit
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human IL1R2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human IL1R2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human IL1R2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human IL1R2 in the samples is then determined by comparing the OD of the samples to the standard curve.
Mouse IL1R2(Interleukin 1 Receptor Type II) ELISA Kit
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse IL1R2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse IL1R2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse IL1R2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse IL1R2 in the samples is then determined by comparing the OD of the samples to the standard curve.
Mouse IL1R2(Interleukin 1 Receptor Type II) ELISA Kit
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse IL1R2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse IL1R2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse IL1R2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse IL1R2 in the samples is then determined by comparing the OD of the samples to the standard curve.
Human Interleukin-36 beta(Interleukin-36 beta) ELISA Kit
The changes in gene amplification most genes (97%), whereas the gene deletion, missense mutations, and truncating mutations are very rare. 7/35 (20%) genes have a more significant change in the primary neuroendocrine prostate cancer (NEPC) of primary adenocarcinoma (AC). 23/35 (66%) genes have a more significant change in NEPC metastasis of AC metastasis. Only three genes (S100A7, S100A8 and S100A9) have a more significant change in NEPC metastasis of AC metastases with neuroendocrine features. Most of the changes in NEPC metastasis gene is a gene amplification (80%), whereas the gene deletion, missense mutations, and truncating mutations are very rare.
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