Genetic Analyses of Contributions of Viral Interleukin-6 Interactions and Signaling to Human Herpesvirus 8 Productive Replication

Genetic Analyses of Contributions of Viral Interleukin-6 Interactions and Signaling to Human Herpesvirus 8 Productive Replication

Human herpesvirus 8 (HHV-8) virus interleukin-6 (vIL-6) is a cytokine that is secreted and most poorly translated into the endoplasmic reticulum (ER). Has been involved, along with HHV-8 viral proteins pro-inflammatory and / or other angiogenic, in HHV-8-related Kaposi’s sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD), in addition to an MCD -related disorders involving elevation of systemic pro-inflammatory cytokines, including human vIL-6 and IL-6 (HIL-6). In this disease, lytic (productive) replication, in addition to viral latency, is believed to play an important role.

Pro-replication activity of vIL-6 has been identified experimentally in PEL and endothelial cells, but the relative contribution of different vIL-6 interaction has not been established. productive interaction of vIL-6 to IL-6 signal transducer, gp130, can occur in the ER, but vIL-6 also interact in the ER with a receptor called vitamin K epoxide non-signal reductase subunit complex 1 variant-2 (VKORC1v2), calnexin, and VKORC1v2- and related calnexin protein UDP-glucose: glycoprotein glucosyltransferase 1 (UGGT1) and glucosidase II (GlucII). Here, we report a systematic characterization of the interaction-modified vIL-6 variants and recombinant virus expressing the lytic phenotype selected variants.

Our data identifies the importance of vIL-6 and the activity of ER-localized it through gp130 to replicate productively in iSLK (induced epithelial) cells, the lack of involvement of detectable vIL-6 interaction with VKORC1v2, GlucII or UGGT1, and the insufficiency and lack of effect of direct contributions from extracellular signals by vIL-6 or Hil-6. These findings, obtained through genetic-based approach, complementing and extending the previous analysis of vIL-6 activity.IMPORTANCE Human herpesvirus 8 (HHV-8) -encoded viral interleukin-6 (vIL-6) was the first viral IL-6 homologues to be identified.

Experimental and clinical evidence indicates that vIL-6 is important for the onset and / or progression of the pathology associated with HHV-8 B-cells, and endothelial, including AIDS-related Kaposi’s sarcoma and multicentric Castleman’s disease. Protein is unusual in poor secretion of the cells and the intracellular activity; interact, directly or indirectly, with a number of outer protein IL-6 signal transducer, gp130, and may mediate this interaction activities through the endoplasmic reticulum.

Here, we characterize in connection with protein interactions and signal transducing activity of vIL-6 variant panels and take advantage of HHV-8 virus mutants expressing variant selected in the phenotypic analysis. Our findings establish the importance of vIL-6 in HHV-8 replication productive and individual contributions interaction of vIL-6 protein to HHV-8 lytic biology. This work furthers the understanding of the biological importance of vIL-6 and a unique intracellular interactions.

 Genetic Analyses of Contributions of Viral Interleukin-6 Interactions and Signaling to Human Herpesvirus 8 Productive Replication
Genetic Analyses of Contributions of Viral Interleukin-6 Interactions and Signaling to Human Herpesvirus 8 Productive Replication

Impact of interleukin IL-6 rs-1474347 and IL-10-rs 1800896 susceptibility genetic polymorphisms in Egypt HCV-infected patients to hepatocellular carcinoma

The hepatitis C virus (HCV) is considered a major cause of cirrhosis and hepatocellular carcinoma (HCC). We aimed to determine the relationship of IL-6 and IL-10 single nucleotide polymorphisms with the development of chronic hepatitis C (CHC) infection to cirrhosis and liver cancer.

IL-2 Interleukin-2 Human Recombinant Protein, Yeast

PROTP60568-3 Regular: 10ug
EUR 317
Description: Interleukin-2 Human Recombinant produced in yeast is a single, glycosylated polypeptide chain containing 134 amino acids and having a molecular mass of 14 kDa. The IL-2 is purified by proprietary chromatographic techniques.

IL-29 Interleukin-29 Human Recombinant Protein, Sf9

PROTQ8IU54-3 Regular: 10ug
EUR 317
Description: Interleukin-29 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 187 amino acids (20-200a.a.) and having a molecular mass of 20.8kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa).;IL29 is fused with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

IL-4 Interleukin-4 Human Recombinant Protein, His Tag

PROTP05112-3 Regular: 20ug
EUR 317
Description: Interleukin-4 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 150 amino acids fragment (25-153) and having a total molecular mass of 17.2kDa.;The IL-4 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

IL-6 Interleukin-6 Human Recombinant Protein, His Tag

PROTP05231-3 Regular: 50ug
EUR 317
Description: IL-6 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 204 amino acids fragment (30-212) and having a total molecular mass of 23.1kDa with a 20 aa N-terminal His tag. ;The IL-6 His is purified by proprietary chromatographic techniques.

Anti-IL-6 Antibody

A00102-3 1mL
EUR 1232
Description: Rabbit Polyclonal IL-6 Antibody. Validated in IP, WB and tested in Human.

IL-8 Interleukin-8 (1-77 a.a.) Human Recombinant Protein, (CXCL8) Pichia

PROTP10145-3 Regular: 25ug
EUR 317
Description: Interleukin-8 Human Recombinant produced in Yeast is a single, glycosylated polypeptide chain containing 79 amino acids and having a molecular mass of 9 kDa. ;The IL-8 is purified by proprietary chromatographic techniques.

Recombinant Human IL-36 Gamma (IL-1F9) Protein

PROTQ9NZH8-3 10ug
EUR 317
Description: The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36γ is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36γ signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36γ also functions as an agonist of NF-kappaB, and can stimulate the inflammatory response in bronchial epithelial cells. Recombinant human IL-36γ is a 17.0 kDa protein containing 152 amino acid residues.

Anti-14-3-3 alpha + beta Rabbit Monoclonal Antibody

M02431-3 100ug/vial
EUR 397
Description: Rabbit Monoclonal 14-3-3 alpha + beta Antibody. Validated in Flow Cytometry, IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat.

Recombinant Murine IL-6 Protein

PROTP08505-3 10ug
EUR 317
Description: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 187 amino acid residues.

Recombinant Murine IL-22 Protein

PROTQ9JJY9-3 50ug
EUR 317
Description: IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant murine IL-22 is a 33.4 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains.

Recombinant Human IL-17B Protein

PROTQ9UHF5-3 25ug
EUR 317
Description: IL-17B is a disulfide-linked homodimer of two 161 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17B is expressed by T-cells and has been shown to stimulate release of TNF-α and IL-1β from cells of the monocyte lineage. Recombinant human IL-17B is a 36.6 kDa non-disulfide-linked homodimer of two 161 amino acid polypeptide chains.

Mouse IL-10 Recombinant Protein

R00021-3 5ug/vial
EUR 259
Description: IL-10 is an anti-inflammatory cytokine and a member of the IL-10 family of cytokines, which have indispensable functions in many infectious and inflammatory diseases. Mouse IL-10 Recombinant Protein is purified interleukin-10 produced in yeast.

Equine IL-13 Recombinant Protei

R00077-3 5ug/vial
EUR 259
Description: IL-13 is an important mediator of allergic inflammation and disease. In addition to effects on immune cells, IL-13 is implicated as a central mediator of the physiologic changes induced by allergic inflammation in many tissues. Equine IL-13 Recombinant Protein is purified interleukin-13 produced in yeast.

Equine IL-6 Recombinant Protein

R00102-3 5ug/vial
EUR 259
Description: Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. Equine IL-6 Recombinant Protein is purified interleukin-6 produced in yeast.

Swine IL-15 Recombinant Protein

R00212-3 5ug/vial
EUR 259
Description: Interleukin-15 (IL-15) is a cytokine with structural similarity to IL-2 that is secreted by mononuclear phagocytes following infection by virus(es). This cytokine induces cell proliferation of natural killer cells. Swine IL-15 Recombinant Protein is purified interleukin-15 produced in yeast.

Equine IL-4 Recombinant Protein

R00230-3 5ug/vial
EUR 259
Description: IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Equine IL-4 Recombinant Protein is purified interleukin-4 produced in yeast.

Equine IL-2 Recombinant Protein

R00387-3 5ug/vial
EUR 259
Description: Interleukin-2 (IL-2) is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial to the regulation of the immune response. Equine IL-2 Recombinant Protein is purified interleukin-2 produced in yeast.

Human IL-17A Recombinant Protein

R00421-3 5ug/vial
EUR 259
Description: IL-17A is a member of the IL-17 family of cytokines, whose members are involved in numerous immune regulatory functions. IL-17 induces the production of many other cytokines, chemokines, and prostaglandins. Human IL-17A Recombinant Protein is purified interleukin-17A produced in yeast.

Chicken IL-8 Recombinant Protein

R00423-3 5ug/vial
EUR 259
Description: Interleukin-8 (IL-8), also known as CXCL8, is an ELR-positive CXC family member chemokine produced by macrophages and other cell types such as epithelial cells. ELR-positive CXC chemokines such as IL-8 specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. Chicken IL-8 Recombinant Protein is purified interleukin-8 produced in yeast.

Ovine IL-21 Recombinant Protein

R00459-3 5ug/vial
EUR 259
Description: Studies suggest that IL-21 is a key component of CD4 T cell help that is required for maintaining the CD8+ T cell responses and inducing B cell antibody response. It is also implicated in the development of autoimmune disease and has antitumor activity.

Dolphin IL-1ra Recombinant Protei

R00651-3 5ug/vial
EUR 259
Description: Interleukin-1 Receptor Antagonist Protein (IL-1F3, IL-1ra) belongs to the IL-1 family of cytokines, whose members play key roles in the development and regulation of inflammation. IL-1 receptor antagonist (IL-1ra; IL-1F3) reduces inflammation by blocking the binding of the agonist receptor ligands. Dolphin IL-1 Receptor Antagonist Recombinant Protein is purified interleukin-1 receptor antagonist protein (IL-1F3, IL-1ra) produced in yeast.

Recombinant Human IL-9 Protein

PROTP15248-3 10ug
EUR 317
Description: IL-9 is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes. IL-9 enhances the proliferation of T lymphocytes, mast cells, erthroid precursor cells and megakaryoblastic leukemia cell lines. Over-expression of IL-9 has been implicated in the pathogenesis of anaplastic lymphoma and Hodgkin's disease. Whereas murine IL-9 can function on human cells, human IL-9 is inactive on mouse cells. Recombinant human IL-9 is a 14.0 kDa protein of 127 amino acid residues including 10 cysteine residues which are fully conserved between the human murine proteins.

Recombinant Human IL-10 Protein

PROTP22301-3 10ug
EUR 317
Description: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant human IL-10 is an 18.6 kDa protein of 161 amino acid residues.

Recombinant Human IL-13 Protein

PROTP35225-3 10ug
EUR 317
Description: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells.  Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites.  IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8.  IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE.  Blocking of IL-13 activity inhibits the pathophysiology of asthma.  Human and murine IL-13 is cross-species reactive.  Recombinant human IL-13 is a 12.6 kDa protein consisting of 115 amino acid residues.

Recombinant Human IL-15 Protein

PROTP40933-3 10ug
EUR 317
Description: IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowel disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant human IL-15 is a 12.9 kDa protein consisting of 114 amino acid residues.

Anti-VEGF Receptor 3/FLT4 Antibody

A01276-3 100ug/vial
EUR 334

Recombinant Human IL-1 Alpha Protein

PROTP01583-3 10ug
EUR 317
Description: IL-1α is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant human IL-1α is an 18.0 kDa protein containing 159 amino acid residues.

Recombinant Human IL-1 Beta Protein

PROTP01584-3 10ug
EUR 317
Description: IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant human IL-1β is a 17.3 kDa protein containing 153 amino acid residues.

Equine IL-1 beta Recombinant Protein

R00101-3 5ug/vial
EUR 259
Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Equine IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast.

Equine IL-1 alpha Recombinant Protein

R01144-3 5ug/vial
EUR 259
Description: IL-1 alpha (IL-1α, IL-1F1) is a member of the interleukin 1 family of cytokines. IL-1 alpha is an inflammatory cytokine active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. Equine IL-1 alpha Recombinant Protein is purified interleukin-1 alpha cytokine produced in yeast.

Swine IL-12 p40 Recombinant Protein

R01152-3 5ug/vial
EUR 259
Description: The IL-12 p40 subunit, or interleukin-12 beta subunit, is the 40 kD cytokine receptor-like subunit of the heterodimeric cytokines IL-12 and IL-23. IL-12 is involved in the differentiation of naive T cells into Th1 cells and the growth and function of T cells. Both IL-23 and IL-12 can activate the transcription activator STAT4 and stimulate the production of interferon-gamma (IFNG). Swine IL-12 p40 Recombinant Protein is purified interleukin-12 p40 produced in yeast.

Recombinant Human IL-12 p40 Protein

PROTP29460-3 10ug
EUR 317
Description: Interleukin-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23. Recombinant human IL-12 p40 is a 40 kDa protein containing 306 amino acid residues.

Anti-active Caspase-3 Rabbit Monoclonal Antibody

M00334-3 100ug/vial
EUR 397
Description: Anti-active Caspase-3 Rabbit Monoclonal Antibody tested for IF, IHC, ICC, WB in Human

Anti-Galectin 3/LGALS3 Antibody (monoclonal, 12B12)

M00621-3 100ug/vial
EUR 334

Individual Reaction Mix 3

G065-3 200 reactions
EUR 167

3-D Life Thioglycerol

T10-3 180 µl
EUR 48

Recombinant Rat IL-13 (113 a.a.) Protein

PROTP42203-3 10ug
EUR 317
Description: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. Recombinant rat IL-13 is a 12.3 kDa protein consisting of 113 amino acid residues.

Recombinant Human IL-16 (121 a.a.) Protein

PROTQ14005-3 10ug
EUR 317
Description: IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 13.3 kDa protein consisting of 129 amino acid residues.

Anti-Glyceraldehyde 3-Phosphate Dehydrogenase [GAPDH] Monoclonal Antibody

M00227-3 100ul
EUR 397
Description: Mouse Monoclonal Glyceraldehyde 3-Phosphate Dehydrogenase [GAPDH] Antibody. Validated in IHC, WB and tested in Equine.

Western Blot Box - 2 7/8 x 1 3/16 x 3/4in.; 7.3 x 3 x 1.9cm

B1200-3 5/pack
EUR 63.77
Description: Western Blot Boxes

TGF-b-3 Transforming Growth Factor-Beta 3 Human Recombinant Protein, Plant

PROTP10600-3 Regular: 5ug
EUR 317
Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. ;The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques.

pLenti-CARM1 shRNA-3 Plasmid

PVTBAV03691-3 2 ug
EUR 356

pLenti-CTLA4 shRNA-3 Plasmid

PVTBAV05689-3 2 ug
EUR 356

pLenti-FOXM1 shRNA-3 Plasmid

PVTBAV08732-3 2 ug
EUR 356

pLenti-JUN shRNA-3 Plasmid

PVTBAV11741-3 2 ug
EUR 356

pLenti-LHX6 shRNA-3 Plasmid

PVTBAV12881-3 2 ug
EUR 356

pLenti-MAGEA3 shRNA-3 Plasmid

PVTBAV13661-3 2 ug
EUR 356

pLenti-RUNX3 shRNA-3 Plasmid

PVTBAV20583-3 2 ug
EUR 356

pLenti-Slc7a11 shRNA-3 Plasmid

PVTBAV21973-3 2 ug
EUR 356

pLenti-STAT3 shRNA-3 Plasmid

PVTBAV22921-3 2 ug
EUR 356

Dr. P Kit-Solution 3

K2021010-3 50 ml
EUR 133
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

3-D Life PEG-Link

L50-3 3x 200 µl
EUR 94

3-D Life CD-Link

L60-3 3 x 200 µl
EUR 321

3-D-Life SG-PVA

M81-3 3x 170 µl
EUR 148

3-D Life FG-PVA

M82-3 3x 170 µl
EUR 148

3-D Life FG-Dextran

M92-3 3x 170 µl
EUR 157

3-D Life RGD Peptide

P10-3 3x 1 µmol
EUR 276

Recombinant Human MMP-3 Protein

PROTP08254-3 10ug
EUR 317
Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-3 degrades fibronectin, laminin, collagens III, IV, and X, and cartilage proteoglycans. Recombinant human MMP-3 is a 42.8 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (378 amino acids).

3-D Life SG-Dextran

M91-3 3x 170 µl
EUR 157

Interleukin-3/IL-3

E21-P39 10ug
EUR 343

Caspase-3 Inhibitor Q-DEVD-OPh

1175-3
EUR 533

3-D Life Scrambled RGD Peptide

P11-3 3x 1 µmol
EUR 276

Rabbit Complement 3-4 WK (100-mL)

31061-3 100mL
EUR 1102.48

QuantiMir 3'-Universal Primer (10,000 qPCR reactions)

RA420AU-3 10,000 assays
EUR 178

SeraMir 3'-Universal Primer (10,000 qPCR reactions)

RA800P-3 10,000 reactions
EUR 178

FSH (Human Follicle-stimulating hormone) ELISA test

3 96T/Box Ask for price
Description: ELISA based test for quantitative detection of FSH (Human Follicle-stimulating hormone)

IL17A Human, Interleukin 17A Human Recombinant Protein, Sf9

PROTQ16552-3 Regular: 10ug
EUR 317
Description: IL17A produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (24-155 a.a.) and fused to a 6 aa His Tag at C-terminus containing a total of 138 amino acids and having a molecular mass of 15.9kDa.;IL17A shows multiple bands between 13.5-28kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.

IL17F Human, Interleukin 17F Human Recombinant Protein, sf9

PROTQ96PD4-3 Regular: 5ug
EUR 317
Description: IL17F produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 142 amino acids (31-163 a.a.) and having a molecular mass of 16kDa (Molecular size on SDS-PAGE will appear at approximately 18-28 kDa). IL17F is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

3-D Life 10x CB-Buffer (pH 5.5)

B10-3 600 µl
EUR 44

3-D Life 10x CB Buffer (pH 7.2)

B20-3 600 µL
EUR 44

Caspase-3 DEVD-R110 Fluorometric HTS Assay Kit

30009-3 1KIT
EUR 809
Description: Minimum order quantity: 1 unit of 1KIT

Human Interleukin-3 (IL-3) Antibody

30128-05111 150 ug
EUR 261

PLGF3 Human, Placenta Growth Factor-3 Human Recombinant Protein, sf9

PROTP49763-3 Regular: 25ug
EUR 317
Description: PLGF3 Human Recombinant produced in Spodoptera frugiperda is a glycosylated homodimer containing 2 chains of 203 amino acids (Leu19-Arg221) and having a molecular mass of 58kDa.;The PLGF-3 is purified by proprietary chromatographic techniques.

IL-3, Interleukin-3, human

RC212-14 2ug
EUR 104.38

IL-3, Interleukin-3, monkey

RC222-14 2ug
EUR 104.38

IL-3, Interleukin-3, canine

RC242-14 2ug
EUR 104.38

IL-3, Interleukin-3, rat

RC252-14 2ug
EUR 101.33

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

M1030-3
EUR 441

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

M1031-3
EUR 436

TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions)

M1032-3
EUR 436

TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions)

M1033-3
EUR 436

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 3 reactions)

M1034-3
EUR 332

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 3 reactions)

M1035-3
EUR 430

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 3 reactions)

M1036-3
EUR 430

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 3 reactions)

M1037-3
EUR 430

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 3 reactions)

M1039-3
EUR 436

ANGPTL3 (17-460)Human Angiopoietin-like Protein 3 (17-460 a.a.) Human Recombinant Protein

PROTQ9Y5C1-3 Regular: 10ug
EUR 317
Description: ANGPTL3 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 453 amino acids (17-460 a.a.) and having a molecular mass of 52.9kDa (Migrates at 25-70kDa on SDS-PAGE under reducing conditions). 

Lethal factor Protease Substrate 3, AMC derivative MEk2 peptide substrate for high-throughput screening of LF inhibitors (14aa)

LFPS-3 1 mg
EUR 408

IL-3, Interleukin-3, murine (mouse)

RC232-14 2ug
EUR 104.38

Human Interleukin-3 (IL-3) Antibody (Biotin Conjugate)

30128-05121 150 ug
EUR 369

Rabbit Interleukin 3,IL-3 ELISA Kit

CN-00724R1 96T
EUR 452

Rabbit Interleukin 3,IL-3 ELISA Kit

CN-00724R2 48T
EUR 302

Chicken Interleukin 3,IL-3 ELISA Kit

CN-00791C1 96T
EUR 434

Chicken Interleukin 3,IL-3 ELISA Kit

CN-00791C2 48T
EUR 284

PoFAine interleukin 3,IL-3 ELISA Kit

CN-01254P1 96T
EUR 452

PoFAine interleukin 3,IL-3 ELISA Kit

CN-01254P2 48T
EUR 302

Rat Interleukin 3,IL-3 ELISA KIT

CN-01500R1 96T
EUR 434

Rat Interleukin 3,IL-3 ELISA KIT

CN-01500R2 48T
EUR 284

Mouse Interleukin 3,IL-3 ELISA KIT

CN-02449M1 96T
EUR 447

Mouse Interleukin 3,IL-3 ELISA KIT

CN-02449M2 48T
EUR 296

Human Interleukin 3,IL-3 ELISA KIT

CN-03207H1 96T
EUR 434

Human Interleukin 3,IL-3 ELISA KIT

CN-03207H2 48T
EUR 284

Human Interleukin 3, IL-3 ELISA KIT

CSB-E04631h-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 3, IL-3 in samples from serum, plasma. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 3, IL-3 ELISA KIT

1-CSB-E04631h
  • EUR 500.00
  • EUR 3402.00
  • EUR 1820.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 3, IL-3 in samples from serum, plasma. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Interleukin 3, IL-3 ELISA KIT

CSB-E04632m-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 3, IL-3 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Interleukin 3, IL-3 ELISA KIT

1-CSB-E04632m
  • EUR 500.00
  • EUR 3402.00
  • EUR 1820.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 3, IL-3 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Interleukin 3, IL-3 ELISA KIT

CSB-E07436r-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 3, IL-3 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Interleukin 3, IL-3 ELISA KIT

1-CSB-E07436r
  • EUR 603.00
  • EUR 4247.00
  • EUR 2260.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 3, IL-3 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Chicken Interleukin 3, IL-3 ELISA Kit

CSB-E09877Ch-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Chicken Interleukin 3, IL-3 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Chicken Interleukin 3, IL-3 ELISA Kit

1-CSB-E09877Ch
  • EUR 627.00
  • EUR 4447.00
  • EUR 2364.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Chicken Interleukin 3, IL-3 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Interleukin 3(IL-3)ELISA Kit      

GA-E0074MS-48T 48T
EUR 336

Mouse Interleukin 3(IL-3)ELISA Kit      

GA-E0074MS-96T 96T
EUR 534

Rabbit Interleukin 3,IL-3 ELISA Kit

GA-E0115RB-48T 48T
EUR 326

Rabbit Interleukin 3,IL-3 ELISA Kit

GA-E0115RB-96T 96T
EUR 524

Rabbit Interleukin 3,IL-3 ELISA Kit

GA-E0116RB-48T 48T
EUR 326

Rabbit Interleukin 3,IL-3 ELISA Kit

GA-E0116RB-96T 96T
EUR 524

Human Interleukin 3(IL-3)ELISA Kit

GA-E0133HM-48T 48T
EUR 289

Human Interleukin 3(IL-3)ELISA Kit

GA-E0133HM-96T 96T
EUR 466

Rat Interleukin 3(IL-3)ELISA Kit

GA-E0140RT-48T 48T
EUR 317

Rat Interleukin 3(IL-3)ELISA Kit

GA-E0140RT-96T 96T
EUR 496

IL-3 Interleukin-3 Mouse Recombinant Protein

PROTP01586 Regular: 10ug
EUR 317
Description: Interleukin-3 mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 135 amino acids and having a molecular mass of 15100 Dalton. ;The IL-3 is purified by proprietary chromatographic techniques.

IL-3 Interleukin-3 Rat Recombinant Protein

PROTP04823 Regular: 20ug
EUR 317
Description: Interleukin-3 Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 144 amino acids and having a molecular mass of 16.3kDa. ;The IL-3 is purified by proprietary chromatographic techniques.

IL-3 Interleukin-3 Human Recombinant Protein

PROTP08700-1 Regular: 10ug
EUR 317
Description: Interleukin-3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 133 amino acids and having a molecular mass of 15000 Dalton. The IL-3 is purified by proprietary chromatographic techniques.

Human Interleukin 3,IL-3 ELISA KIT

201-12-0094 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Interleukin 3 (IL-3) CLIA Kit

abx195892-96tests 96 tests
EUR 825

Mouse Interleukin 3 (IL-3) CLIA Kit

abx195893-96tests 96 tests
EUR 825

Rat Interleukin 3 (IL-3) CLIA Kit

abx195894-96tests 96 tests
EUR 825

IL-3 beta, Interleukin-3-beta, rat

RC252-14B 5ug
EUR 101.33

Rat IL-3(Interleukin-3) ELISA Kit

ER0040 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml

Mouse IL-3(Interleukin 3) ELISA Kit

EM0116 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 9.375pg/ml

Chicken IL-3(Interleukin 3) ELISA Kit

ECH0043 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Chicken;Sensitivity: 9.375pg/ml

Human IL-3(Interleukin 3) ELISA Kit

EH0196 96T
EUR 476.25
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

Human Interleukin 3(IL-3)ELISA Kit

QY-E04273 96T
EUR 361

Rat Interleukin 3(IL-3)ELISA Kit

QY-E11513 96T
EUR 361

Mouse Interleukin 3(IL-3)ELISA Kit

QY-E20857 96T
EUR 361

Rabbit Interleukin 3,IL-3 ELISA Kit

QY-E30183 96T
EUR 374

Porcine interleukin 3 (IL-3) ELISA Kit

QY-E40139 96T
EUR 400

Chicken Interleukin 3,IL-3 ELISA Kit

QY-E80039 96T
EUR 426

Anti-CNP Antibody

M01017-3 100ul
EUR 397
Description: Chicken Polyclonal CNP Antibody. Validated in IHC, WB and tested in Equine, Pig.

Anti-GAP43 Antibody

M01868-3 100ul
EUR 397
Description: Rabbit Polyclonal GAP43 Antibody. Validated in IF, IHC, WB and tested in Bovine, Chicken, Equine, Human, Mouse, Pig, Rat.

Anti-Calretinin Antibody

M04255-3 100ul
EUR 397
Description: Rabbit Polyclonal Calretinin Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-Nanog Antibody

A00153-3 100ug/vial
EUR 294

Anti-IL17C Antibody

A00164-3 100ug/vial
EUR 294

Anti-AICDA Antibody

A00267-3 100ug/vial
EUR 294

Anti-ICOS Antibody

A00291-3 100ug/vial
EUR 334

Anti-TLR1 Antibody

A00429-3 100ug/vial
EUR 334

Anti-IGFBP3 Antibody

A00435-3 100ug/vial
EUR 294

Anti-IL17B Antibody

A10846-3 100ug/vial
EUR 294

Anti-RAB3GAP2 Antibody

A07244-3 100ug/vial
EUR 334

Anti-FOXI1 Antibody

A07512-3 100ug/vial
EUR 334

Anti-TANK Antibody

A00445-3 100ug/vial
EUR 334

Anti-FGF23 Antibody

A00478-3 100ug/vial
EUR 294

Anti-Leptin Antibody

A00479-3 100ug/vial
EUR 294

Anti-CD5 Antibody

A00480-3 100ug/vial
EUR 334

Anti-SYK Antibody

A00490-3 100ug/vial
EUR 294

Anti-PON1 Antibody

A00516-3 100ug/vial
EUR 334

Anti-CSF1 Antibody

A00620-3 100ug/vial
EUR 294

Anti-LBP Antibody

A00809-3 100ug/vial
EUR 294

Anti-IL22 Antibody

A00963-3 100ug/vial
EUR 294

Anti-MBL2 Antibody

A01000-3 100ug/vial
EUR 294

Anti-KCNH1 Antibody

A01036-3 100ug/vial
EUR 294

Anti-IL12B Antibody

A01152-3 100ug/vial
EUR 334

Anti-PRMT1 Antibody

A01417-3 100ug/vial
EUR 294

Anti-TFF3 Antibody

A01738-3 100ug/vial
EUR 334

Anti-IFNAR2 Antibody

A02056-3 100ug/vial
EUR 334

Anti-IL17F Antibody

A02062-3 100ug/vial
EUR 294

Anti-TREM1 Antibody

A02135-3 100ug/vial
EUR 294

Anti-SENP1 Antibody

A02156-3 100ug/vial
EUR 294

Anti-RBMS3 Antibody

A12416-3 100ug/vial
EUR 334

Anti-BTC Antibody

A02171-3 100ug/vial
EUR 334

Anti-EEA1 Antibody

A02296-3 100ug/vial
EUR 294

Anti-JAK3 Antibody

A02598-3 100ug/vial
EUR 294

Anti-APRT Antibody

A02721-3 100ug/vial
EUR 334

Anti-CUL2 Antibody

A02986-3 100ug/vial
EUR 334

Anti-EIF4A1 Antibody

A03922-3 100ug/vial
EUR 334

Anti-SLIT1 Antibody

A04113-3 100ug/vial
EUR 294

For comparison purposes, the four groups were registered; groups of chronic hepatitis C (CHC, n = 22), related to HCV-group liver cirrhosis (HCV-LC, n = 22), related to HCV-group of HCC (HCV-HCC, n = 54), and a control group that looked healthy (control , n = 48). HCC diagnosis and staging are in concordance to the Barcelona Clinic Liver Cancer (BCLC) staging system. IL-6 rs-1474347 and IL-10-rs 1800896 genotype performed by allele (VIC- and FAM-labeled) discrimination method using test-on-demand real-time TaqMan PCR test.

Djoumana

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