Interleukin 4 Genetics for Cell Culture

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Enhancing immune responses by a novel multi-epitope ROP8 DNA vaccine plus interleukin-12 plasmid as a genetic adjuvant against acute Toxoplasma gondii infection in BALB/c mice

Enhancing immune responses by a novel multi-epitope ROP8 DNA vaccine plus interleukin-12 plasmid as a genetic adjuvant against acute Toxoplasma gondii infection in BALB/c mice

Background: Toxoplasmosis is a widespread zoonotic infection, caused by the obligate intracellular protozoan. The infection is often asymptomatic in immunocompetent individuals, although in people with impaired immune systems can cause severe complications and progressive. constant efforts scientists have made valuable discoveries in the development of Toxoplasma gondii (T. gondii) vaccine candidate. However, an effective vaccine has not been developed yet. In the current study, we tested the co-delivery of multi-epitope vaccine pcROP8 new plasmid DNA encoding IL-12 (pcIL-12) to assess immune responses in BALB / c mice against acute T. gondii infection.


Methods: BALB / c mice were immunized on days 0, 21, and 42. The immune response of the vaccinated and control groups were evaluated using measurements of cytokines and antibodies, lymphocyte proliferation test, and survival time.


Results: The findings show that immunization with a multi-epitope pcROP8 significantly increase the level of anti-T. gondii antibodies, cellular immune responses TH1-type, lymphocyte proliferation, and survival time is long, compared with the control group (P <0.05). Furthermore, the use of pcIL-12 as an adjuvant genetic causes enhancement of the immune response mentioned above BALB / c mice (P <0.05).


Conclusion: The co-administration of pcIL-12 with a multi-epitope vaccine pcROP8, can be managed to increase the level of protection. Thus, this immunization regimen may be an effective vaccine strategies against T. gondii acute infection.

 Enhancing immune responses by a novel multi-epitope ROP8 DNA vaccine plus interleukin-12 plasmid as a genetic adjuvant against acute Toxoplasma gondii infection in BALB/c mice
Enhancing immune responses by a novel multi-epitope ROP8 DNA vaccine plus interleukin-12 plasmid as a genetic adjuvant against acute Toxoplasma gondii infection in BALB/c mice

Genetic Variants FOXP3 Do Not Impact Supply and Cervical Interleukin-10 Levels in Human Papillomavirus Infection in Women

Regulatory T cells (Treg) heredity plays a central role in the control of inflammation and autoimmunity. Interleukin-10 (IL-10) has been described as a pleiotropic cytokine that is mainly released by CD4 + CD25 + FOXP3 + Treg and has strong immunosuppressive activity. Forkhead box P3 (FOXP3) expression of the transcription factor is very important for Treg function as a suppressor cells and FOXP3 gene single nucleotide variants (SNVs) has been shown to influence the pathogenesis of the virus.

This study was conducted to evaluate the plasmatic and cervical level of IL-10 in patients papillomavirus infected and uninfected humans and investigate whether intron -1 FOXP3 SNVs rs3761548 and rs2232365 may alter IL-10 secretion. SNVs characterization genotyped by polymerase chain reaction (PCR) products based on a specific sequence of enzymatic cleavage using restriction fragment length polymorphism method (RFLP). IL-10 levels determined by quantitative enzyme-linked immunosorbent assay (ELISA). In conclusion, the data show that there is no relationship between FOXP3 and cervical SNVs and circulating IL-10 level. These findings provide a reason that the IL-10 gene activation is independent of the transcription factor FOXP3 activity on Treg cells.


Introduction: We aimed to determine the genetic polymorphism and serum levels of interleukin 18 in Fars ethnic groups.Material and methods: 226 Fars ethnic groups participate. ATP III criteria were used to assess components of MS. SNP of the IL-18 gene was determined by ARMS-PCR.Results: The GG, GC and CC genotypes of -137 is 50%, 40% and 10%. CC, CA and AA genotypes of -607 is 45%, 37%, and 18% ..

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Recombinant Human Interleukin-2/IL-2

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EUR 120
Description: Lyophilized from a 0.2 μm filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 4.0.

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EUR 936
Description: Lyophilized from a 0.2 μm filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 4.0.

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EUR 674.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 4.0.

Recombinant Human Interleukin-2/IL-2

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EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 4.0.

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EUR 465.3

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Description: Lyophilized from a 0.2 μm filtered solution of 10mM Acetata-Na, 5% Trehaiose, pH 4.5.

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Description: Lyophilized from a 0.2 μm filtered solution of 10mM Acetata-Na, 5% Trehaiose, pH 4.5.

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Description: Lyophilized from a 0.2 μm filtered solution of 10mM Acetata-Na, 5% Trehaiose, pH 4.5.

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Description: Lyophilized from a 0.2 μm filtered solution of 10mM Acetata-Na, 5% Trehaiose, pH 4.5.

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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

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EUR 674.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

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EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

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PB180634-250uL4 250u L×4
EUR 30
Description: Supplements & Reagents

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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH 7.4.

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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH 7.4.

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EUR 674.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH 7.4.

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CX66-50ug 50ug
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH 7.4.

Recombinant Human Interleukin-2 (rHu IL-2) 22MIU

AR1002-0022 22MIU
EUR 3840

IL-2 Interleukin-2 Human Recombinant Protein, HEK

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EUR 380.4
Description: Interleukin-2 Human Recombinant produced in HEK cells is a glycosylated monomer, having a total molecular weight of 15kDa.;The IL2 is purified by proprietary chromatographic techniques.

IL-2 Interleukin-2 Human Recombinant Protein, Yeast

PROTP60568-3 Regular: 10ug
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Description: Interleukin-2 Human Recombinant produced in yeast is a single, glycosylated polypeptide chain containing 134 amino acids and having a molecular mass of 14 kDa. The IL-2 is purified by proprietary chromatographic techniques.

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IL-2 Interleukin-2 Human Recombinant Protein, His Tag

PROTP60568-2 Regular: 10ug
EUR 380.4
Description: Interleukin-2 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 133 amino acids fragment (21-153) having a molecular weight of 20kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. _x000D_ The IL-2 His is purified by proprietary chromatographic techniques._x000D_

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  • 100 ug
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  • 200 ug
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Description: Recombinant Bovine Interleukin 2 expressed in: E.coli

Recombinant Interleukin 2 (IL2)

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  • 100 ug
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Description: Recombinant Chicken Interleukin 2 expressed in: E.coli

Recombinant Interleukin 2 (IL2)

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  • 100 ug
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Description: Recombinant Guinea pig Interleukin 2 expressed in: E.coli

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  • 100 ug
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Description: Recombinant Human Interleukin 2 expressed in: E.coli

Recombinant Interleukin 2 (IL2)

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  • 100 ug
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Description: Recombinant Mouse Interleukin 2 expressed in: E.coli

Recombinant Interleukin 2 (IL2)

4-RPA073Po01
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  • 100 ug
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Description: Recombinant Pig Recombinant Interleukin 2 (IL2) expressed in: E.coli

Recombinant Interleukin 2 (IL2)

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  • 100 ug
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Description: Recombinant Rat Interleukin 2 expressed in: E.coli

Recombinant Interleukin 2 (IL2)

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EUR 642.6

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EUR 421.3

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EUR 517

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Recombinant Interleukin 2 (IL2)

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EUR 415.8

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EUR 2434.9

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EUR 441.1

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EUR 603.9

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EUR 489.6

Recombinant Murine Interleukin-2

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EUR 7350

Mouse Interleukin-2 (IL-2) Recombinant

IMSIL2R25UG each
EUR 482
Description: Mouse Interleukin-2 (IL-2) Recombinant

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EUR 283
Description: Mouse Interleukin-2 (IL-2) Recombinant

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CC092-002 2ug
EUR 351.6

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EUR 489.6

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EUR 4272

Porcine Interleukin-2 (Recombinant)

22060634-1 2 µg
EUR 146.42

Canine Interleukin-2 (IL-2) Recombinant

ICNIL2R25UG each
EUR 482
Description: Canine Interleukin-2 (IL-2) Recombinant

Canine Interleukin-2 (IL-2) Recombinant

ICNIL2R5UG each
EUR 283
Description: Canine Interleukin-2 (IL-2) Recombinant

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P1814 100ug Ask for price
Description: Recombinant protein for human Interleukin-13 receptor subunit alpha-2

Recombinant Human Interleukin-10

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Recombinant Human Interleukin-10

CC054-002 2ug
EUR 351.6

Recombinant Human Interleukin-10

CC054-010 10ug
EUR 489.6

Recombinant Human Interleukin-10

CC054-101 1mg
EUR 10752

Recombinant Human Interleukin-11

CC057-002 2ug
EUR 351.6

Recombinant Human Interleukin-11

CC057-010 10ug
EUR 489.6

Recombinant Human Interleukin-11

CC057-101 1mg
EUR 10752

Recombinant Human Interleukin-12

CC058-002 2ug
EUR 351.6

Recombinant Human Interleukin-12

CC058-010 10ug
EUR 489.6

Recombinant Human Interleukin-12

CC058-100 100ug
EUR 3462

Recombinant Human Interleukin-13

CC061-002 2ug
EUR 351.6

Recombinant Human Interleukin-13

CC061-010 10ug
EUR 489.6

Recombinant Human Interleukin-13

CC061-101 1mg
EUR 10752

Recombinant Human Interleukin-15

CC063-002 2ug
EUR 351.6

Conclusion: IL-18 genes may differ in certain populations, different ethnic groups and geographic regions. IL-18 polymorphisms may not be used as a marker of metabolic syndrome.

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